頁籤選單縮合
題 名 | Promotion of Forskolin-Induced Long-Term Potentiation of Synaptic Transmission by Caffeine in Area CA1 of the Rat Hippocampus |
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作 者 | Lu,Kwok-tung; Wu,Shang-peng; Gean,Po-wu; | 書刊名 | 中國生理學雜誌 |
卷 期 | 42:4 1999.12[民88.12] |
頁 次 | 頁249-253 |
分類號 | 361.19 |
關鍵詞 | Caffeine; Long-term potentiation; Forskolin; Adenosine; Hippocampus; c-AMP; |
語 文 | 英文(English) |
英文摘要 | Caffeine which is present in soft drinks has been shown to increase alertness and allays drowsiness and fatigue. The aim of this study is to investigate whether caffeine could produce a long-term effect on the synaptic transmission using extracellular recording technique in the hippocampal slices. Bath application of caffeine (100 μ M) reversibly increased the slope of field excitatory postsynaptic potential (fEPSP). Forskolin (25 μ M) by its own did not affect the fEPSP significantly. However, i the presence of caffeine, forskolin induced a long-term potentiation (LTP) of fEPSP. Enprofylline which has been shown to exhibit some actions like caffeine but with a low adenosine antagonistic potency did not affect the normal synaptic transmission or the effect of forskolin at a lower concentration (10 μ M). However, when the concentrations were increased to 20 and 50 μ M, enprofylline significantly enhanced the fEPSP slope and promoted forskolin-induced LTP. The parallel increase of fEPSP and promotion of LTP observed with enprofylline suggests that adenosine A □ antagonism is the primary mechanism behind caffeine's effect. This hypothesis was further strengthened by the finding that promotion of forskolin-induced LTP was mimicked by the non-xanthine adenosine antagonist 9-chloro-2-(furyl)[1,2,4] triazolo [1,5-C] quinazolin-5-amine (CGS 15943). The promotion of forskolin-induced LTP provides a cellular basis behind caffeine's increase in capacity for sustained intellectual performance. |
本系統中英文摘要資訊取自各篇刊載內容。