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頁籤選單縮合
題名 | Hypothesis-Origin of Parietal Cells: Transfer of the H狇K狇-ATPase Gene from Parasitic Microorganisms to Cnidaria? |
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作者姓名(外文) | Okabe,Susumu; | 書刊名 | 中國生理學雜誌 |
卷期 | 42:3 1999.09[民88.09] |
頁次 | 頁121-128 |
分類號 | 364.6 |
關鍵詞 | H狇-ATPase; Gastric H狇K狇-ATPase; Parietal cells; Yeast; Symbiosis; Gene transfer; |
語文 | 英文(English) |
英文摘要 | Parietal cells present in the stomach and terminal ileum secrete a highly-concentrated hydrochloric acid into the lumen. The cells are characterized by the enzyme P-type H ? K ? -ATPase, which has an ± -subunit with a high homology (>85%) for the amino acid sequences of frog, mouse and pig stomachs. Gastric H? K? -ATPase also exhibits a high homology to H? -ATPase in yeast and Na? K? -ATRase in many tissues, suggesting origination from a common ancestral ATPase. It is known that parietal cells first appeared in fish and were later expressed in evolutionarily-higher organisms. Primitive organisms, such as Cnidaria and Ctenophora, that possessed digestive organs, but not parietal cells, were abundant in the ocean more than 600 million years ago (Pre-Cambrian period). The author thus hypothesized that the genes of either H ? -ATPase or H? K? -ATPase that were present in parasitic microorganisms, such as yeast, were transferred to the interstitial cells of host organisms, such as Cnidaria, eventually leading to the evolution of parietal cells. It appears that although parietal cells in the stomach developed by chance, such cells have greatly contributed to the evolution of advanced organisms, including humans, by affording safe ingestion of a large volume of various foods. |
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