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題 名 | Differential Effects of Different Cytokines on the Tumorigenicity and Immunogenicity of Murine Tumors=不同細胞激素對老鼠腫瘤的成長與免疫力有不同的影響 |
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作 者 | 陳育民; 蔡俊明; 彭瑞鵬; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:11 1999.11[民88.11] |
頁 次 | 頁807-816 |
分類號 | 414.82 |
關鍵詞 | 細胞激素; 顆粒吞噬球生成素; 第四介白質; 第十介白質; 第十二介白質; 黑色素瘤細胞株; Cytokine; Granulocyte-macrophage colony stimulating factor; Interleukin-4; Interleukin-10; Interleukin-12; Melanoma cell line; |
語 文 | 英文(English) |
中文摘要 | 背景:有文獻報告,將顆粒吞噬球生成素或其它細胞激素的基因轉入腫瘤細胞後,可製成較有效的腫瘤疫苗。但此步驟耗時,且臨床上不可能使用於每一個病患身上。 方法:本試驗使用經照射後的B-16癌細胞株,將它與不同的細胞激素合併處理,以探討可否增加腫瘤疫苗的效果,進而避免或減少皮下腫瘤的生長或肺部轉移的發生。 結果:體外試驗結果發現,在加上第二或第四介白質後,脾臟細胞毒殺癌細胞的能力達到最高。老鼠接受1-3次疫苗注射後,其免疫後的脾臟細胞對癌細胞的毒殺能力亦很類似。經過疫苗注射後的脾臟細胞的增生反應比普通的脾臟細胞強。從皮下腫瘤生長模式與肺部轉移模式中均可發現,先疫苗注射後才接受腫瘤的挑戰,可廷緩腫瘤生長的速度,並延長老鼠的壽使;而疫苗注射1次或多次的效果是一樣的。如果於疫苗注射的同時使用第四介白質,對抑制皮下腫瘤生長會有更好的效果;至於同時使用第十二介白質,則對肺部轉移的抑制較好。 結論:即使在同種的老鼠與腫瘤中,不同的細胞激素對不同的腫瘤生長方式均可能有不同的影響。就如本試驗的第四介白質,對抑制皮下腫瘤生長效果較佳,而第十二介白質則對抑制腫瘤肺部轉移效果較好。臨床上,當醫師考慮使用腫瘤疫苗預防腫瘤復發時,應考慮到以上這些因素。 |
英文摘要 | Background: Granulocyte-macrophage colony stimulating factor (GM-CSF) or other cytokine gene transfer into tumor cells makes an effective tumor vaccine. However, this technique is time consuming and it is not possible for routine use in every patient. Methods: The present study was designed to combine use of the irradiated B-16 cell line, a C57BL6 mice melanoma cell line, and cytokine (GM-CSF, interleukin-4 [IL-4], IL-10, or IL-12) manipulation, to enhance effectiveness of the tumor vaccine in prevention or reduction of subcutaneous tumor formation or pulmonary metastases. Results: The results of in vitro studies show that the cytolytic activity of the splenocyte was highest when IL-2 or IL-4 was added to the culture medium. Immune splenocytes demonstrated the same level of cytolytic activity regardless of wheter the mice were immunized once, twice or thrice. The proliferation assay was higher in immune splenocytes compared with normal splenocytes. The results of both the subcutaneous and pulmonary tumor growth models showed that immunization alone retarded tumor growth and prolonged survival, and this effect was essentially the same regardless of the frequency of immunization. However, the effect was much stronger when IL-4 was used during immunization in the subcutaneous tumor model, whereas IL-12 was the most optimal cytokine in the pulmonary metastases model. Conclusions: Different cytokines have different effects on immunization in different animal models even with the same tumor and animal. Careful selection of the appropriate cytokine for tumor vaccine immunization must be considered when different patterns of tumor recurrence are noted in clinical practice. |
本系統中英文摘要資訊取自各篇刊載內容。