頁籤選單縮合
題名 | Calcium Rather than Calcitonin is Dominant to Mediate Gastric Emptying in Thyroidectomized Rats= |
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作者 | Chang,Full-young; Lee,Shou-dong; Doong,Ming-luen; Wang,Paulus S.; |
期刊 | 中國生理學雜誌 |
出版日期 | 19990900 |
卷期 | 42:3 1999.09[民88.09] |
頁次 | 頁189-193 |
分類號 | 361.4 |
語文 | eng |
關鍵詞 | Calcium; Calcitonin; Gastric emptying; Gastrointestinal motility; Gastrointestinal transit; Thyroidectomy; |
英文摘要 | Both calcium and calcitonin are important in mediating gastrointestinal motility. Present study tried to study what was the dominant role of calcitonin or calcium replacement on the gastric emptying in thyroidectomized animals. Adult Sprague-Dawley male rats received thyroidectomy or sham operation and then housed for two weeks until motility study, which was conducted using radiochromium to measure gastric emptying. Before motility study these rats were i.p. injected with saline or human calcitonin in the doses of O.l, l and 10 ? gM/kg, respectively. Another group of thyroidectomized rats received i.v. infusion of saline or CaCl A for 30 min before motility study. Among thyroidectomized rats, neither saline nor various doses of calcitonin treatment disturbed gastric emptying compared to this of sham operated rats. Thyroidectomy diminished plasma calcium level, however, additional calcitonin treatment did not restore the suppressed calcium level (P<0.01). Of rats following saline or CaCl A infusion, thyroidectomy did not change gastric emptying, whereas CaCl A infusion enhanced gastric emptying (P<0.05). In conclusion, exogenous calcium treatment further enhances gastric emptying in thyroidectomized rats, whereas calcitonin replacement has no effect on gastric emptying. We suggest that calcium rather than calcitonin is dominant to mediate gastric emptying. |
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