頁籤選單縮合
題名 | Effects of L-Glutamic Acid on Acid Secretion and Mucosal Blood Flow in the Rat Stomach= |
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作者 | Tsai,Li Hsueh; Huang,Lih Ron; Chen,Sheng-hhsuan; Liu,Hung-jung; Chou,Liang-shung; |
期刊 | 中國生理學雜誌 |
出版日期 | 19990900 |
卷期 | 42:3 1999.09[民88.09] |
頁次 | 頁181-187 |
分類號 | 361.132 |
語文 | eng |
關鍵詞 | L-glutamic acid; Histamine; Oxotremorine; Non-NMDA receptor; Gastric acid secretion; Gastric mucosal blood flow; |
英文摘要 | The effect of intravenous administration of L-glutamic acid (L-Glu) on gastric acid secretion and gastric mucosal blood flow (GMBF) in anesthetized rats were investigated. Infusion wi{h synthetic L-Glu alone had no effect on spontaneous acid secretion. However, L-Glu reduced histamine-(2 mg/kg/hr) or oxotremorine- (1 ? g/kg/hr) stimulated acid secretion, whereas L-Glu had no effect on acid secretion induced by pentagastrin (8? g/kg/hr). Furthermore, this inhibitory effect of L-Glu on histamine- or oxotremorine-stimulated acid secretion was blocked by 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA receptor antagonist. The effect of L-Glu on gastric mucosal microcirculation in the anesthetized rats was evaluated by using Laser Doppler Flowmetry (LDF). The results showed that L-Glu did not significantly reduce both mucosal and serosal blood flow in stomach. No significant modulatory effect on histamine- or oxotremorine-stimulated increase in GMBF was noted after infusion with L-Glu.It is concluded that L-glutamic acid is capable of the modulating of gastric acid secretion via ionotropic non-NMDA receptors, but do not affect on GMBF. However, L-glutamic acid showed no effect on acid secretion by itself. |
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