頁籤選單縮合
題名 | Effects of Endothelin-1 on Duodenal Bicarbonate Secretion and Mucosal Integrity in Rats= |
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作者 | Takeuchi,Koji; Sugamoto,Shinichi; Suzuki,Keizo; Kawauchi,Shoji; Furukawa,Osamu; |
期刊 | 中國生理學雜誌 |
出版日期 | 19990900 |
卷期 | 42:3 1999.09[民88.09] |
頁次 | 頁129-135 |
分類號 | 361.4 |
語文 | eng |
關鍵詞 | Endothelin-1; Prostacyclin; Acid secretion; HCO[feb0][fed2]secretion; Duodenal lesion; |
英文摘要 | Effects of endothelin-1 on gastric acid secretion, duodenal HCO? secretion, and duodenal mucosal integrity were investigated in anesthetized rats, in comparison with those of TV-10957, a stable analogue ofprostacyclin. A rat stomach mounted on an ex-vivo chamber or a proximal duodenal loop was perfused with saline, and gastric acid or duodenal HCO ? secretion was measured using a pH-stat method and by adding 100 mM NaOH or 10 mM HCI, respectively. Duodenal lesions were induced by mepirizole (200 mg/kg) given subcutaneously. Intravenous administration of endothelin-1 (0.6 and 1 nmol/kg) caused an increase of duodenal HCO? secretion with concomitant elevation of blood pressure; this effect was antagonized by co-administrahon of BQ-123 (ET? antagonist; 3 mg/kg, i.v.) and significantly mitigated by vagotomy. Likewise, endothelin-1 caused a significant decrease in histamine-stimulated acid secretion, and this effect was also significantly antagonized by BQ-123. Although TV-10957 (10 and 30 mg/kg, i.v.) produced a temporal decrease of blood pressure, this agent caused not only an increase of duodenal HCO ? secretion, independent of vagal nerves, but also a decrease of acid secretion as well. In addition, both endothelin-1 and TV-10957 significantly prevented mepirizole-induced duodenal lesions at the doses that caused an increase of duodenal HCO ? secretion and a decrease of gastric acid secretion. These results suggest that endothelin-1 affects the duodenal mucosal integrity by modifying both gastric acid and duodenal HCO ? secretions, the effects being mediated by ETA receptors. tors. |
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