頁籤選單縮合
題 名 | Stability of Extemporaneous Suspensions of Co-trimoxazole |
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作 者 | 林慧玲; 沈麗娟; 楊浚琦; 陳春雄; | 書刊名 | 中華藥學雜誌 |
卷 期 | 51:1 1999.02[民88.02] |
頁 次 | 頁93-102 |
分類號 | 418.1 |
關鍵詞 | Co-trimoxazole; Extemporaneous suspension; Stability; |
語 文 | 英文(English) |
英文摘要 | Spectrometric assay according to the British Pharmacopoeia 1993 and Ph values were used to determine the stability of co-trimoxazole in 2 extemporaneous Suspensions under refrigeration or at room temperature in light-resistant containers for 28-94 days. The suspensions contained 4 % w/v sulfamethoxazole and 0.8 % w/v trimethoprim in either simple syrup or HSC (1 % w/v methyl-cellulose: simple syrup = 7:3) vehicle. The suspensions were easily re-dispersed. All samples showed no signs of caking or flocculation. Co-trimoxazole simple syrup suspension was more easily prepared and more stable than HSC-vehicle suspension. Trimethoprim in co-trimoxazole simple syrup suspension maintained a concentration of 100±10% of the initial value for at least 20 days at both room temperature or under refrigeration. Sulfamethoxazole concentration remained at 100±10% of the initial value even after 94 days. The pH values remained within the pH range specified by both the USP and BP for at least 94 days. At both room temperature or under refrigeration, trimethoprim in corimoxazole HSY vehicle suspension remained at 100±10% of the initial value for at least 14 days. Sulfamethoxazole concentration remained at 100±10% of the initial value even after 28 days. The pH values remained within the pH range specified by both the IJSP and BP for at least 63 days. It is recommended that co-trimoxazole tablets be triturated and simple syrup added to make a suspension at a concentration of one single strength tablet per 10 mL. The suspension should be stored in a light-resistant container, refrigerated, and used within 20 days. |
本系統中英文摘要資訊取自各篇刊載內容。