頁籤選單縮合
題名 | 臺灣居民對白喉之免疫性=Immunity Against Diphtheria in Taiwan |
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作 者 | 李漢芳; 鄭麗容; 樂怡雲; 吳盈昌; | 書刊名 | 微免與感染雜誌 |
卷期 | 32:3 1999.09[民88.09] |
頁次 | 頁206-212 |
分類號 | 415.2723 |
關鍵詞 | 白喉免疫性; 白喉抗體; 白喉免疫球蛋白; 毒素中和實驗; 組織培養毒素中和檢測法; Immunity to diphtheria; Diphtheria antibody; Diphtheria immunoglobulin; Toxin neutralization test; Toxin neutralization test by VERO cell; |
語文 | 中文(Chinese) |
中文摘要 | 為了了解目前臺灣居民對白喉之保護能力,取臺北市中山區與大同區作為都市地 區代表, 臺北縣金山鄉作為鄉村地區代表,利用非洲綠猴腎細胞( VERO cell )抗體毒素 中和實驗,對兩地區居民做白喉抗體之力價分析,以期對國人白喉免疫性做一全面性之研究 。 包括 0 歲至 91 歲年齡群,依年齡隨機取樣檢測:臺北市 594 件,金山鄉 645 件。檢 測結果, 整體陽性率(白喉抗體力價≧ 0.01 IU ╱ mL )為 79.9 %; 14 歲以下孩童為 97.0 %; 20-29 歲群降到最低點為 38.0 %,且鄉村地區遠低於都市地區,金山鄉陽性率 為 20.0 %( 12 ╱ 60 );臺北市為 60.4 %( 29 ╱ 48 ); 30 歲以上逐漸上升,至 50 歲以上族群,抗體陽性率在 88.1 %以上。 臺灣地區自民國 44 年( 1955 )起執行白 喉、百日咳、破傷風三合一疫苗預防接種後,至民國 63 年後已無死亡病例,按照我國現行 政策, 孩童祇於 6-7 歲追加一劑破傷風、白喉類毒素混合疫苗,成年人無法自環境中感染 得到抗體,故隨著疫苗接種時間拉長而造成抗體力價降低,本研究結果,可作為我國白喉疫 苗追加接種計畫之參考。 |
英文摘要 | The vaccination of combined diphtheria, pertussis, and tetanus (DPT) vaccine provides good immunity against childhood diphtheria in Taiwan. However, a waning protective antibody level has been observed with an increase in age. Therefore, we assessed diphtheria immunoglobulin (DIG) level in Taipei City as representatives of urban dwellers and in King-Shan County as representatives of rural dwellers to evaluate the status of immunity against diphtheria in the population of Taiwan. In total, 1239 serum samples collected from the resident population, age 0-91 years, were detected by toxin neutralization test with VERO cells. The DIG level ≧ 0.01 IU/mL was considered to be seropositive and ≧ 0.1 IU/mL was considered to be fully protective. The positive rate and fully protective rate for all persons were 79.9% and 36.6%, respectively. The age specific positive rate and fully protective rate for children under 14 years of age were 97.0% and 78.0%, for 20-29 years of age group, were 38.0% and 8.3%, respectively, to be the lowest record among tested age groups. Then, both rates increased proportionately with age. Among those birth cohorts born in the diphtheria immunization era (since 1955), the antibody levels were inversely correlated with age, suggesting a decreased opportunity for exposure to natural diphtheria infection in the recent years and the duration of the vaccine inoculation. This finding indicates the need of a booster vaccination for young adults to ensure a full term protection and a long lasting diphtheria control. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。