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- High-Risk Human Papillomavirus Deoxyribonucleic Acid as an Adjunct Marker in Cervical Cytology
- Misclassification of Human Papillomavirus Infection in Epidemiological Studies: Nature and Consequences
- Understanding the Epidemiology of Genital Human Papillomavirus Infection in Women: Importance of Data on Type-Specific Infections
- Correlation between Viral Load of High-Risk HPV and Severity of Cervical Intraepithelial Neoplasia in Women Older than 50 Years Old
- Papanicolaou Smear and HPV Testing for Cervical Screening
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頁籤選單縮合
題名 | High-Risk Human Papillomavirus Deoxyribonucleic Acid as an Adjunct Marker in Cervical Cytology=高危險群人類乳突瘤病毒-核酸之檢測作為子宮頸篩檢輔助性的指標 |
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作者 | 林政道; 曾志仁; 周宏學; 黃寬仁; 張廷彰; 賴瓊慧; 宋永魁; | 書刊名 | 長庚醫學 |
卷期 | 22:3 1999.09[民88.09] |
頁次 | 頁409-415 |
分類號 | 417.2832 |
關鍵詞 | 子宮頸上皮內贅生瘤; 人類乳突瘤病毒; 三明治捕捉式分子雜交法; Cervical intraepithelial neoplasm; CIN; Human papillomavirus; Hybrid capture method; |
語文 | 英文(English) |
中文摘要 | 背景:為改善子宮頸篩檢的準確度和精確度,利用子宮頸細胞分化程度與高危險 群人類乳突瘤病毒出現頻率相符;於是結合高危險群人類乳突瘤病毒─核酸檢測與子宮頸抹 片的臨床價值評估。 方法:由1997年2月至1997年12月,利用三明治捕捉式分子雜交法(Hybrid Capture) 來偵測高危險群人類乳突瘤病毒─核酸檢驗,共有114位因子宮頸抹片異常作為子宮鏡檢查 及高危險群人類乳突瘤病毒─核酸檢測(病毒型16,18,31,33,35,39,45,51,56,58,59,68)。 結果:在子宮頸抹片結果有高度分化的上皮內贅生瘤為24位,具有低度分化的上皮內 贅生瘤為38位,具有非特異性上皮細胞病變為52位;在子宮頸抹片結果併具有高危險群人 類乳突瘤病毒─核酸檢測率,高度分化的上皮內贅生瘤為76%,在低度分化的上皮內贅生 瘤為61%,具有非特異性上皮細胞病變為37%;若高危險群人類乳突瘤病毒─核酸檢測與 子宮頸抹片併用,對子宮頸上皮內贅生瘤或癌症而言,其敏感度升高至91%。 結論:本研究顯示利用偵測高危險群人類乳突瘤病毒─核酸檢驗,可以改善子宮頸抹片 準確率,尤其在具有非特異性上皮細胞病變或低度分化的上皮內贅生瘤中。在此研究顯示有 臨床上及統計上的意義,因此建議能利用三明治捕捉式分子雜交法來偵測高危險群人類乳突 瘤病毒─核酸的生化指標,及結合子宮頸抹片,來早期診斷子宮頸上皮內贅生瘤或癌症。 |
英文摘要 | Background: This study was designed to determine whether screening for high-risk human papillomaviruses testing could improve the detection of cervical dysplasia anad cancer in assistance with conventional Papanicoloau (Pap) smears. Methods: The study was based on 114 patients with abnormal Pap smears referred for colposcopy from Feb. 1997 to Dec. 1997. The presence of high-risk human papillomavirus (HPV) DNA was determined with the Hybrid Capture method (including HPV types 16,18,31,33,35,39,45,51,52,56,58,59, and 68). Cytologic examination by Papanicolaou smear was based on the Bethesda system and cervical biopsy was done via colposcopy. Results: Cytologic examination demonstrated high-grade squamous intraepithelial lesions (HSIL) in 24 patients with HPV positive (75%). low-grade squamous intraepithelial lesions (LSIL) in 38 with 61% HPV positive, and atypical squamous cells of undetermined significance (ASCUS) in 52 with 37% HPV positive. Among patients with a cytologic diagnosis of borderline abnormalities (ASCUS or LSIL), those with who were HPV positive were significantly more likely to have cervical dysplasia (both p<0.05). The sensitivity of combined HPV assay and/ or cytology for detection of noninvasive precursor (91%) was significantly greater than those of cytology (68%) or HPV assay (81%) alone. Conclusion: The addition of the hybrid capture high-risk HPV DNA assay to cytologic examination of cervical smears appears to increase the sensitivity of cervical screening. Our findings suggest that HPV DNA may be a useful adjunct marker for early detection of cervical dysplasia in women with minimally abnormal Pap smears (ASCUS/low-grade SIL). |
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