頁籤選單縮合
題名 | Effects of Adrenergic Antagonists on LH Surge in Short-Term Ovariectomized-Steroids-Primed Rats=腎上腺素拮抗劑對卵巢類固醇激素在卵巢初除鼠引發黃體激素潮放的影響 |
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作者 | 單萬邦; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 23:3 1999.07[民88.07] |
頁次 | 頁120-125 |
分類號 | 415.121 |
關鍵詞 | 腎上腺素拮抗劑; 卵巢類固醇; 卵巢初除鼠; 黃體激素潮放; Luteinizing hormone; Adrenergic antagonists; Ovariectomy; Ovarian steroids; |
語文 | 英文(English) |
英文摘要 | Characterization of adrenergic stimuli on luteinizing hormone (LH) release induced by ovarian steroids in short-term ovariectomized (OVX) rats was studied. Female Sprague-Dawley rats were OVX about 1000 h on the diestrous day 1. After ovariectomy, rats were immediately inserted estradiol-containing Silastic capsules s.c. and implanted atrial Silastic tubing for frequent blood samplings. All the rats received 2 mg of progesterone s.c. at 0930 h the next morning. At 1200 h, the rats received additional treatments: a saline vehicle, prazosin HC1 (an al- adrenergic antagonist), yohimbine HCl (an a2-adrenergic antagonist), or propranolol HCl (a b-adrenergic antagonist) s.c., respectively. Two different doses of individual adrenergic antagonists were used on an equimolar basis in order to show their effectiveness on steroids-induced LH secretion. Blood samples were collected before and 1, 3, and 5 hours after the treatments through indwelt tubings. LH surge induced by ovarian steroids was suppressed/delayed by prazosin and yohimbine, but potentiated by propranolol in a dose-dependent manner. Results suggested that the hypothalamic a1-, a2-, and b-adrenoreceptors were involved in the control of LH surge in the short-term OVX-steroids-primed rats. Principally, the a1- and a2-adrenoreceptors played a facilitatory role, and the b-adrenoreceptors played an inhibitory role in the regulation of LH surge induced by ovarian steroids. |
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