頁籤選單縮合
題 名 | 蟾酥複方之抗炎鎮痛及急性肝毒性研究=Evaluate Anti-Inflammatory, Analgesic Effect and Hepatotoxicity on Bofonis Herbal Preparation |
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作 者 | 蔡佳蓉; 林鉅超; | 書刊名 | 嘉南學報 |
卷 期 | 24 1998.11[民87.11] |
頁 次 | 頁20-27 |
分類號 | 414.5 |
關鍵詞 | 蟾酥複方; 抗炎鎮痛; 急性肝毒性; Bofonis herbal preparation; Anti-inflammatory; Analgesic; Acute hepatotoxicity; |
語 文 | 中文(Chinese) |
中文摘要 | BUFA1是由蟾酥 (Bufonis Venenum)、青黛 (Indigo Naturalis)、黃芩 (scutellariae Radix) 和珍珠末 (Margarita) 按重量以 1:9:91:5 的比例所組成的複方。 大白鼠在餵食 100mg/kg 的劑量後,能明顯的減緩 Carrageenin 及 Serotonin 所引發的下 肢足蹠水腫 (Hind-paw edema)。大白鼠在去除腎上腺之後,BUFA1 則無抗水腫的作用,顯 示 BUFA1 抗水腫效用與腎上腺有關。 另外在餵食相同劑量下,BUFA1 能減少小白鼠腹腔注 射醋酸 (0.1m1/10g) 後所引起的後肢伸張 (Writhing Response) 次數。然而,對於熱板所 引起的疼痛則無止痛作用。 在毒性分析實驗中發現, 大白鼠連續餵食 1 週的 BUFA1 (100mg/kg/day) 後, 其血中白血球 (WBC) 和紅血球 (RBC) 的數目以及血紅素 (Hemoglobin) 的量並不會受到影響, 而且肝功能的指標 (SGOT, SGPT 及 Alkaline Phosphatase) 也沒有顯著的變化。除此之外,大白鼠在餵食高劑量 (15g/kg) 的 BUFA1 後 ,在 24 小時之內並無任何一隻大白鼠死亡的現象 (n=15)。綜合以上的結果得知 BUFA1 能 有效的減緩發炎反應,但是不具明顯的鎮痛作用,而且 BUFA1 是一安全性高的複方。 |
英文摘要 | BUFA1 is a traditional Chinese medical preparation composed of Bofonis Venenum、 Indigo Naturalis、 Scutellariae Radix and Margarita in the ratio of 1:9:9:5 Oral adminstration of BUFA1 (100mg/kg) markedly reduced carrageenin and serotonin induced edema in hind paw of the rat and this anti-inflammatory effect of BUFA1 was influenced by adrenal glands. In the same dosage, BUFA1 sighificantly attenuated writhing response of the mice triggered by (i.p.) acetic acid. However, it failed to relieve the pain caused by hot plate. There were no significant changes of blood cell components, including red blood cell, white blood cell and hemoglobin content, as well as liver function tests (SGOT, SGPT and Alkaline phosphatase activity) in the rat after feeding BUFA1 (100mg/kg) for a week. In addition, the rat can tolerate BUFA1 as high as 150-fold dosage used for anti-inflammation. In conclusion, BUFA1 exhibits an anti-inflammatory effect that is influenced by adrenal glands. BUFA1 has no significat analgestic action and it appears to be safe. |
本系統中英文摘要資訊取自各篇刊載內容。