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題 名 | Design and Synthesis of Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate-Mediated Biological Recognition |
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作 者 | 翁啟惠; | 書刊名 | Journal of the Chinese Chemical Society |
卷 期 | 46:3 1999.06[民88.06] |
頁 次 | 頁271-281 |
分類號 | 418.41 |
關鍵詞 | Carbohydrates; Carbohydrate mimetics; Glycosyltransfer enzyme inhibitors; Aminoglycoside antibiotic mimetics; Selectins; Sialyl lewis x; |
語 文 | 英文(English) |
英文摘要 | Carbohydrates have been known as poor candidates for drug development. Recent studies have, however, shown that structurally simplified small molecules as mimics of complex carbohydrates recognized by receptors can be developed as inhibitors of carbohydrate-mediated biological recognition. In addition, small molecules with higher affinity and specificity than the parent ligands can be developed by incorporating additional hydrophobic or charged groups in the carbohydrate mimetic which contains essential functional groups for receptor binding. Representative examples are illustrated in the studies of sialy Lewis x - selectin interactions, glycosidase and glycosyltransferase reactions and aminoglycoside antibiotic - RNA interactions. |
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