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頁籤選單縮合
題名 | Antimicrobial Susceptibility of Clostridium difficile by E Test=艱難梭狀桿菌的抗微生物劑敏感性試驗 |
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作者姓名(中文) | 鄭舒倖; 朱芳業; 羅世慧; 盧章智; | 書刊名 | 微免與感染雜誌 |
卷期 | 32:2 1999.06[民88.06] |
頁次 | 頁116-120 |
分類號 | 418.284 |
關鍵詞 | 艱難梭狀桿菌; 抗微生物劑; 敏感性試驗; Clostridium difficile; E test; Minmum inhibitory concentration; |
語文 | 英文(English) |
中文摘要 | 我們針對 44 株臨床分離出的艱難梭狀桿菌( Clostridium difficile )進行十 一種抗生素的敏感性試驗。以 E 試驗偵測最小抑菌濃度。Metronidazole,teicoplanin 及 vancomycin 的 MIC □分別為 0.38 μ g/mL, 0.75 μ g/mL,及 1.0 μ g/mL,效果很好 。 而大多數的難難梭狀桿菌則對 imipenem,cefoxitin,clindamycin,及 ciprofloxacin 有明顯的抗藥性。Teicoplanin 尚未有人用來治療艱難梭狀桿菌感染,但我們建議值得進行 臨床試驗。 並且提醒臨床醫師, 當治療腹腔感染或厭氧菌感染時, 如果選用的藥物(如 imipenem,cefoxitin,clindamycin 或 ciprofloxacin )是對艱難梭狀桿菌無效的藥物, 應特別留意艱難梭狀桿菌相關的腹瀉問題。 |
英文摘要 | the in vitro inhibitory activity of 11 antimicrobials against 44 clinical isolates of Clostridium difficile was investigated. Minimum inhibitory concentrations (MICs) were determined using E test. Metronidazole (MIC□ 0.38 μg/mL), teicoplanin (MIC□ 0.75μg/mL) and vancomycin (MIC□ 1.0μg/mL) were very active against the isolates examined, whereas, resistance to imipenem, cefoxitin, clindamycin and ciprofloxacin was found in most of the tested strains. We concluded that teicoplanin warrants clinical trials to determine its adequate dosage to treat C. difficile infection. The commonly used regimens to treat intra-abdominal and/or anaerobic infections (eg. imipenem, cefoxitin, clindamycin or ciprofloxacin) need speical attention, while considering the side effects of C. difficile-associated diarrhea. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。