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題名 | Tissue Hepatocyte Growth Factor and Proliferating Cell Nuclear Antigen in Hepatocellular Carcinoma=肝細胞癌組織之肝細胞生長因子及增殖細胞核抗原 |
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作者 | 黃冠棠; 李宣書; 陳健弘; 邱玲玲; 李嘉哲; 陳定信; 許輝吉; 許金川; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 98:2 1999.02[民88.02] |
頁次 | 頁92-96 |
分類號 | 415.5362 |
關鍵詞 | 肝細胞癌組織; 肝細胞生長因子; 增殖細胞核抗原; Hepatocyte growth factor; Proliferating cell nuclear antigen; Hepatocellular carcinoma; Western blot; |
語文 | 英文(English) |
英文摘要 | To better understand the roles of hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) in hepatocellular carcinoma (HCC), 37 surgically resected HCCs and corresponding nontumorous liver tissue specimens were collected and the expression of these two factors was quantified by Western blot analysis. Both HGF and PCNA expression levels were significantly higher in tumor tissue than in nontumorous liver tissue. However, their expression levels in HCC tissue and nontumorous tissue did not show any significant correlation with the recurrence of HCC. In addition, HGF and PCNA did not correlate with Edmondson's grade, invasiveness of tumor, presence of tumor capsule, or tumor size. No correlation was found between the expression levels of HGF and PCNA in HCC tissue. We conclude that, although both HGF and PCNA are present at higher levels in HCC tissue than in nontumorous liver tissue, they play little role in the clinicopathologic manifestations of this tumor. HGF appears to contribute little, if at all, to the proliferative activity of HCC cells. |
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