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題名 | Serum Hepatocyte Growth Factor Levels in Patients with Inflammatory Lung Diseases=測定肺部發炎病人血清中之肝細胞生長因子之研究 |
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作者姓名(中文) | 黃明賢; 蔡米山; 王東衡; 鍾飲文; 候俊君; 林晏君; 黃吉志; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 15:4 1999.04[民88.04] |
頁次 | 頁195-201 |
分類號 | 415.53 |
關鍵詞 | 肺部發炎; 肝細胞生長因子; Hepatocyte growth factor; Inflammatory lung disease; |
語文 | 英文(English) |
中文摘要 | 肝細胞生長因子已被認為在肺部受到傷害之後細胞再生之機轉上有關係,但是肝細胞生長因子在生理上所扮演之角色上,尚有很多不明之處。我們測定肺部發炎病人血中肝細胞生長因子及C反應蛋白來探討其臨床上所代表之意義。我們用ELISA方法測定四十七位肺部發炎病人(包括:十六位肺結核病人、十八位肺炎病人及十三位慢性阻塞性肺疾病病人)血清中肝細胞生長因子同時又測定血清中C反應蛋白。同時又測定了五十位正常人血清中之肝細胞生長因子,作為正常對照組。結果發現肺部發炎病人血清中肝細胞生長因子量比正常人血清中之肝細胞生長因子呈有意義之上昇 (p<0.0001)。慢性阻塞性肺疾病病人血清中之肝細胞生長因子比肺炎或肺結核病人血清中之肝細胞生長因子呈有意義之低 (p<0.05)。肺部發炎病人血清中之肝細胞生長因子和血清中C反應蛋白成有意義之線性相關(r=0.48,p=0.00087)。當肺部發炎病人病情進步時,病人血清中之肝細胞生長因子也呈有意義之下降。由我們研究之結果,肝細胞生長因子在呼吸系統發炎時氣管上皮細胞之修補上可能扮演一 種很重要之角色,今後值得進一步做更深入研究。 |
英文摘要 | HGF is a pulmotrophic factor in the regeneration of an injured lung. However, the physiological role of HGF in vivo remains largely unknown. We studied HGF in patients with inflammatory lung diseases to investigate the clinical significance of HGF and compared with C-reactive protein (CRP) in inflammatory lung diseases. Forty-seven patients with inflammatory lung diseases (16 tuberculosis, 18 pneumonia, and 13 chronic obstructive pulmonary disease (COPD) were studied. Fifty normal, healthy individuals were analyzed as normal control subjects. Senum HGF levels were measured by enzyme-linked immunosorbent assays (ELISA). Serum CRP levels were also performed. The mean±SE numbers of serum HGF levels in the patients with inflammatory lung diseases (4.33±0.41 ng/ml) were significantly elevated when compared with those in normal control subjects (0.36±0.02 ng/ml)(p<0.0001). Serum HGF levels in patients with COPD was significantly lower than those were with tuberculosis or pneumonia (p<0.05). There was a significant correlation between serum HGF levels and CRP in inflammatory pulmonary diseases (r=0.18, p=0.00087). The significantly decreased serum HGF levels in patients with improved inflammatory lung diseases were also observed subsequently. Our results suggest that secreted HGF may play an important role in bronchial epithelium reconstruction during respiratory inflammation. |
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