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題 名 | 放射性氫氧基磷灰石微粒製備及其用於肝癌治療之體外實驗=Preparation and In-Vitro Evaluation of the Radioactive Hydroxyapatite Micron-Sized Particles for Internal Radiotherapy of Hepatoma |
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作 者 | 周鳳英; 謝明發; 鍾仁傑; 劉黃升; 金重勳; 雷永耀; 戚謹文; 劉仁賢; | 書刊名 | 放射治療與腫瘤學 |
卷 期 | 6:3 1999.09[民88.09] |
頁 次 | 頁159-165 |
分類號 | 416.246 |
關鍵詞 | 放射性陶瓷微粒; 體內輻射治療; 肝癌; Radioactive ceramic particles; Internal radiotherapy; Liver cancer; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:本研究製備放射性氫氧基磷灰石陶瓷微粒用於肝癌之體內輻射治療,探討肝 癌細胞對陶瓷微粒之親和性及攝入能力,並以放射性陶瓷微粒處理癌肝細胞,研究其殺傷毒 性。 材料與方法:所製備之放射性陶瓷微粒為具生醫相容性之氫氧基磷灰石陶瓷。中子照射於清華 大學開放水池式反應器中進行,以人類肝癌HepG2細胞進行體外實驗。 結果:中子照射後核種分析得知氫氧基磷灰石陶瓷微粒中主要核種為P-32。細胞實驗顯示陶 瓷微粒與肝癌細胞間有很強的親和性。以較大粒徑者(70~100μm)測試,可見肝癌細胞於三天 內會爬向微粒上生長,並漸漸將之包埋。以粒徑較小之陶瓷微粒(<1μm)試驗結果,可見微粒 會被肝癌細胞內吞噬進入細胞中。以放射性陶瓷微球處理培養中之肝癌細胞,可見其對肝癌 細胞有明顯的殺傷效果,劑量較高時可以立刻殺死肝癌細胞,劑量較低時會被肝癌細胞攝入, 核種在細胞內衰變後造成細胞死亡;立即死亡之細胞形態可見之變異較小,而經數天後死亡之 細胞有較多形態上之變異。 結論:體外研究結果顯示放射性氫氧基磷灰石微粒具高度細胞毒性,應是一有效的肝癌體內輻 射治療治劑。此結果對未來臨床體內輻射治療研究上應具重要意義。 |
英文摘要 | Purpose: The radioactive hydroxyapatite micron-sized particles (RHMP) were prepared for internal radiotherapy of hepatoma. The interaction of hydroxyapatite micron-sized particles (HMP) and the cytotoxicity of RHMP to the hepatoma cells were also studied. Materials and Methods: The RUMP were synthesized using biocompatible hydroxyapatite and neutron irradiated in Tsing-Hua open pool reactor. Human hepatoma HepG2 cell line was employed for in-vitro evaluation. Results: The main nuclide of the RHMP is P-32. Cell culture tested reveals that hepatoma cells have high affinity to HMP. Tested with 70-100 μm HMP, the hepatoma cells climbed and surrounded the particles within 3 days. Testing with sub-micron HMP, the particles were endocytosised by hepatoma cells. Cells treated with higher dosages of RHMP showed lower surviving fraction, and cells seemed to have less morphological changes. Meanwhile, cells were treated with lower dosages, changes were observed and the RHMP could be endocytosised by hepatoma cells. Conclusion: In-vitro evaluation reveals that the RHMP are highly cytotoxic and are an effective internal radio-therapeutic agent for hepatoma. These results may have major clinical significance in the development of future research in internal radiotherapy. |
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