頁籤選單縮合
題名 | Bacterial Sensitivity Test of Antibiotics Loaded Bone Cement Hemei-Spherical Disc--With Special Reference to Heat Stability of Tienam, Pipril, Pefloxacin, Augmentin, Mandol and Fortum |
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作者 | 古鳴洲; 邢福達; 楊玉英; 黃穎峰; | 書刊名 | 中華民國骨科醫學會雜誌 |
卷期 | 16:1 1999.03[民88.03] |
頁次 | 頁25-30 |
分類號 | 416.26 |
關鍵詞 | Bacterial sensitivity test; Antibiotics loaded bone cement discs; Heat stability; Initial elution; |
語文 | 英文(English) |
英文摘要 | New antibiotics including Tienam, Pipril, Pefloxacin, Augmentin, Fortum and Mandol were added into bone cement and made into hemispherical cement discs. The discs were divided into two groups, one heated up to 105 degrees Celsius in autoclave (to reproduce the possible temperature of cement bulk cur-ing in total joint replacement scenario) and another 55 degress Celsius (the tem-perature of EO gas sterilization chamber). The discs were tested with same antibiotic paper discs against some Gram negative bacteria from deep muscu-loskeletal infection with diffusion agar method for susceptibility. The bacterial inhibition zone were measured and recorded. The results showed Pipril and Pefloxacin having good high heat stability and initial elution. Tienam, Fortum andMandol were not high heat stable, but elute well after 55-degree degree processing. They are probably good for using as cement beads, but must be use in caution when added in bulk into bone cement. Augmentin is totally unsatisfactory in this study and should be advised against its application in any circumstances. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。