頁籤選單縮合
題名 | Castleman's Disease in a Single Institution in Southern Taiwan=卡斯托曼病在南臺灣一醫院之經驗 |
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作者 | 連啟惇; 周世華; 吳俊杰; 黃明賢; 楊志仁; Lien, Chi-tun; Chou, Shah-hwa; Wu, Chun-chieh; Huang, Ming-shyan; Yang, Chih-jen; |
期刊 | 胸腔醫學 |
出版日期 | 20130200 |
卷期 | 28:1 2013.02[民102.02] |
頁次 | 頁1-7 |
分類號 | 415.6 |
語文 | eng |
關鍵詞 | 卡斯托曼病; 單一中心型; 透明血管型; Castleman's disease; Unicentric; Hyaline-vascular type; |
中文摘要 | 要:卡斯托曼病是一種少見的淋巴增生性疾病且縱膈腔是最容易被侵犯的地方。因為少見所以它的病因及病理機轉仍然不明,起初的表現可以類似淋巴癌、單一惡性腫瘤、轉移癌或是感染症。依據卡斯托曼病獨特的淋巴結構可以區分為四種病理型態,包括單一中心型(透明血管變異及血漿細胞變異)、多重中心型、及人類皰疹病毒第八型相關的卡斯托曼病。卡斯托曼病的預後與分型有關,單一中心型通常有較好的預後,但是其還是可能會復發或合併其他種類卡斯托曼病與惡性腫瘤同時發生。我們從1990年起至2010年5月回顧高雄醫學大學附設醫院所有以病理確定診斷卡斯托曼病的病例,共計有5例。所有病例皆為單一中心型及透明血管變異。這些病例皆有良好預後,於手術切除診斷後追蹤至少一年以上皆無復發。我們發表這個研究整理及討論我們的發現。 |
英文摘要 | Castleman’s disease (CD) is a very rare lymphoproliferative disease, and the mediastinum is the most commonly involved site. Because of the rarity of CD, its etiology and pathogenesis are still uncertain. The initial impression of a CD-related mass is often that of a lymphoma, solitary malignancy, metastatic carcinoma or an infectious disease, rather than CD. The various types of CD are characterized by their distinctive lymphoid architectural changes in all nodal compartments, and can be divided into 4 types pathologically: unicentric, which has a hyaline vascular variant and a plasma cell variant, multicentric, and a new subtype, HHV-8-associated CD. The prognosis of CD depends on the subtype. The unicentric subtype usually has a good prognosis; however, recurrence or coexistence with malignancies or malignant sequelae is possible. In order to investigate this rare disease and its prognosis, we retrospectively reviewed all patients with CD with pathologically proven samples at Kaohsiung Medical University Hospital from 1990 to 2010. Five cases were recorded, all of which were of the unicentric type and hyaline vascular variant. The diagnoses were made based on surgical excisions, and no cases of recurrence were found after at least 1 year of follow-up, indicating the good prognosis. We present our case review and discuss the findings. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。