頁籤選單縮合
題 名 | No Association of the S20G Mutation of Amylin Gene with Insulin Secretion, Insulin Sensitivity, and Diabetes Mellitus in Taiwanese |
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作 者 | Chuang,Lee-ming; Lee,Kuan-chin; Huang,Chieu-ning; Wu,Huey-pei; Tai,Tong-yuau; Lin,Boniface J.; | 書刊名 | Journal of Genetics and Molecular Biology |
卷 期 | 10:1 1999.03[民88.03] |
頁 次 | 頁1-8 |
分類號 | 362.611 |
關鍵詞 | Amylin gene; Mutation; Insulin secretion; Insulin sensitivity; Taiwanese; |
語 文 | 英文(English) |
中文摘要 | To study the role of the S20G mutation of amylin gene in the pathogenesis of type 2 diabetes, 99 unrelated normal controls, 24 subjects with impaired glucose tolerance, 182 subjects with NIDDM, and 122 subjects with IDDM were recruited in Taiwan. The S20G mutation of amylin gene was detected by polymerase-chain-reaction/restriction-fragment-length-polymorphism and confirmed by DNA sequence analyses. Pedigree members of the families with this mutation were studied by oral glucose tolerance test, glucagon stimulation test, and insulin suppression test. The S20G mutation of the amylin gene was found in 4 (4.4%) in normal control subjects, 1 (4.2%) in 24 subjects with IGT, 2 (1.6%) in subjects with type I diabetes, and 3 (1.6%) in the subjects with type 2 diabetes. Among the non-diabetic pedigree members, subjects with mutation had a reduced response of insulin secretion at 30 min and an increase in plasma glucose concentration at 60 min after oral glucose loading as compared to those without mutation. The maximal insulin secretion was delayed in the subjects with mutations. However, these differences were not found after adjustment with age factor. No difference in the steady-state plasma glucose levels was found between the non-diabetic subjects with or without mutation. In conclusion, S20G mutation of amylin gene does not seem to play a major role in the pathogenesis of type 2 diabetes in Taiwanese. |
英文摘要 | To study the role of the S20G mutation of amylin gene in the pathogenesis of type 2 diabetes, 99 unrelated normal controls, 24 subjects with impaired glucose tolerance, 182 subjects with NIDDM, and 122 subjects with IDDM were recruited in Taiwan. The S20G mutation of amylin gene was detected by polymerase-chain-reaction/restriction-fragment-length-polymorphism and confirmed by DNA sequence analyses. Pedigree members of the families with this mutation were studied by oral glucose tolerance test, glucagon stimulation test, and insulin suppression test. The S20G mutation of the amylin gene was found in 4 (4.4%) in normal control subjects, 1 (4.2%) in 24 subjects with IGT, 2 (1.6%) in subjects with type I diabetes, and 3 (1.6%) in the subjects with type 2 diabetes. Among the non-diabetic pedigree members, subjects with mutation had a reduced response of insulin secretion at 30 min and an increase in plasma glucose concentration at 60 min after oral glucose loading as compared to those without mutation. The maximal insulin secretion was delayed in the subjects with mutations. However, these differences were not found after adjustment with age factor. No difference in the steady-state plasma glucose levels was found between the non-diabetic subjects with or without mutation. In conclusion, S20G mutation of amylin gene does not seem to play a major role in the pathogenesis of type 2 diabetes in Taiwanese. |
本系統中英文摘要資訊取自各篇刊載內容。