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題名 | Pseudomyxoma Peritonei with High Serum CA19-9: Report of Three Cases=腹腔偽黏液瘤併高血清CA19-9值:三例報告 |
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作者姓名(中文) | 郭仲謀; 郭仲煌; 張簡吉幸; 趙景華; 許聰騰; | 書刊名 | 長庚醫學 |
卷期 | 22:1 1999.03[民88.03] |
頁次 | 頁94-99 |
分類號 | 415.5 |
關鍵詞 | 腹腔偽黏液瘤; Pseudomyxoma peritonei; Carbohydrate antigen 19-9; CA19-9; |
語文 | 英文(English) |
中文摘要 | 腹腔偽黏液瘤是一種罕見的腹腔內腫瘤,其特徵是大量的黏液累積在腹腔內。腹 腔偽黏液瘤常常與腸胃道或卵巢的黏液性腫瘤有關。 本文報告 3 例源自於不同病因的腹腔 偽黏液瘤皆合併高血清 CA19-9 值。 第 1 例是源自於分化良好的直腸癌具有血清 CA19-9 值 1132 U ╱ ml,經過開刀與化學治療 1 個月後死於肺炎併發敗血性休克。 第 2 例則是 未知腫瘤來源而具有血清 CA19-9 值 2520 U ╱ ml,經過開刀與化學治療後, 目前存活已 超過 1 年。第 3 例亦是未知腫瘤來源而具有血清 CA19-9 值 679 U ╱ ml 與腹水 CA19-9 值 4580 U ╱ ml,經過開刀治療後,目前存活已超過 3 個月。通常高血清 CA19-9 值會出 現於胰臟癌、膽道癌、大腸直腸癌、胃癌與肝癌。很多文獻報告提出高血清 CA19-9 值與黏 液素腫瘤有關。在免疫化學研究中亦證實 CA19-9 染色會存在於黏液素腫瘤中。腹腔偽黏液 瘤包含非常多的黏液素,因此我們建議在腹腔偽黏液瘤的病人常規測定血清與腹水的 CA19-9 值。 |
英文摘要 | Pseudomyxoma peritonei (PMP) is an unusual form of intraabdominal neoplasm that produces a large amount of extracellular mucin. It is often associated with mucinous tumors of gastrointestinal tract or ovary. Herein, we report 3 patients with pseudomyxoma peritonei with high serum carbohydrate antigen 19-9 (CA19-9) levels. The first patient, who had a CA19-9 level of 1132 U/ml, had well-differentiated rectal cancer and died of chemotherapy complications, pneumonia and septic shock; one month after admission. The other 2 cases with CA19-9 levels of 2520 U/ml and 679 U/ml had tumors of unknown origins and had survived more than 1 year and 3 months after treatment, respectively. Usually, elevated serum CA19-9 levels are found in patients with pancreatic, biliary, colorectal, gastric or liver cancers. However, many studies have shown high serum CA19-9 levels are associated with mucinous carcinoma. Immunochemical studies also showed positive staining of CA19-9 in mucinous tumors. PMP is composed of large amounts of mucin, therefore, we suggest that serum and ascites CA19-9 levels should be routinely checked in patients with PMP. |
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