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題名 | The Hemodynamic Changes of Gastroduodenal Regional Blood Flow after Helicobacter Pylorieradication in Patients with Duodenal Ulcer Scar=十二指腸潰瘍瘢痕期病人根除幽門螺旋桿菌後之胃十二指腸局部血流變化 |
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作者姓名(中文) | 吳登強; 王文明; 盧建宇; 蘇育正; 林綉茹; 劉景勳; 詹昌明; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 15:1 1999.01[民88.01] |
頁次 | 頁19-25 |
分類號 | 415.553 |
關鍵詞 | 十二指腸潰瘍瘢痕期; 幽門螺旋桿菌; 局部血流變化; Hp; Regional blood flow; Duodenal ulcer; |
語文 | 英文(English) |
中文摘要 | 十二指腸潰瘍病人常併有幽門螺旋桿菌感染及伴隨粘膜攻擊因子及防禦因子之間的不平衡,為了解幽門螺旋桿菌 (Hp) 和胃十二指腸局部血流的關係,本研究以雷射都卜勒血流測量儀偵測 26 位十二指腸潰瘍病人的十二指腸潰瘍瘢痕區及胃竇小彎處血流並比較幽門螺旋桿菌根除與否對血流的影響,在 23 位 Hp 根除病人的血流測定後發現胃竇小彎處血流在 Hp 根除後顯著的上升 (p<0.05),但是潰瘍瘢痕處沒有差別,而在 4 位未能根除 Hp 的病人血流都沒有差異,這顯示幽門螺旋桿菌的感染對胃局部血流有顯著的影響。 |
英文摘要 | Duodenal ulcer (DU) is frequently accompanied by Helicobacter pylori (Hp) infection and associated with the imbalance of aggressive factors and defensive factors. To investigate the possible relationship between Hp and regional gastric blood (low, 26 endoscopically proved DU (scar stage) and Hp infection patients were included and received triple therapy (colloid bismuth subcitrate 120 mg qid for 4 weeks, amoxicillin 500 mg qid for 2 weeks and metronidazole 250 mg tid for 2 weeks). Regional gastroduodenal blood flow (RGDF) was measured at DU scar area and antrum lesser curvature site by laser Doppler flowmetry during endoscopic examination, before and one month after triple therapy. In 22 patients with Hp eradication the RGDF was significantly elevated at antrum lesser site after triple therapy (p<0.05) but there was no difference at DU scar area. However, in 4 patients without Hp eradication no difference of RGDF in these two points was found. Therefore, Hp appears to have direct effects on gastric micro-circulation. |
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