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題 名 | Subcutaneous Tumors of Mice Treated with Rhodamine-123 and Laser Irradiation=雷射光照射與若丹明[febe][feb5][feaf][feb0]治療鼷鼠的皮下腫瘤 |
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作 者 | 游智勝; 郝道猛; 林宜信; 黃蕙棻; 陳洸艟; 邱義陽; | 書刊名 | 長庚醫學 |
卷 期 | 22:3 1999.09[民88.09] |
頁 次 | 頁362-369 |
分類號 | 418.94 |
關鍵詞 | 光動力療法; 光敏劑; 若丹明[febe][feb5][feaf][feb0]; 雷射光照; 皮下腫瘤; Photodynamic therapy; Photosensitizer; Rhodamine-123; Laser irradiation; Subcutaneous tumor; |
語 文 | 英文(English) |
中文摘要 | 背景:用光敏劑(photosensitizer)與雷射光照射合併治療腫瘤的方法,稱為光動力療 法(photodynamic therapy, PDT)。本研究之目的在於評估以若丹明 (Rhodamine-123, Rh )當 做光敏劑,與雷射光照射單獨及合併治療鼷鼠皮下腫瘤的療效。 方法:將肉瘤-180細胞(1×10 )接種到ICR種系的雌性鼷鼠的胸部皮下,約經10天就 長成皮下腫瘤,接受雷射光照與光敏劑Rh 單獨及合併之治療,每天1次,連續3天。 結果:結果顯示:以7.5mg/kg的Rh123與75 J/cm 之雷射光照合併治療的效果最佳, 其死亡率為16.7%,腫瘤控制率為83.3%,平均存活時間為109.4天,其增加壽命的比率為 135.8%。至於對腫瘤細胞的抑制效果,以15 mg/kg的Rh 與90 J/cm 的雷射光照射合 併處理為最佳。而且對腫瘤細胞內DNA、RNA及蛋白質的合成速率亦有明顯的抑制。 結論:用若丹明 為光敏劑與雷射光照合併治療鼷鼠的皮下腫瘤有明顯的療效。此種光 動力療法對於腫瘤細胞以及腫瘤細胞內DNA、RNA及蛋白質的合成速率亦有明顯的抑制。 |
英文摘要 | Background:Treatment involving photosensitizers and laser irradiation (LIR) in cancer therapy is known as photodynamic therapy (PDT). The purpose of our study was to assess the therapeutic effect of PDT using rhodamine-123 (Th ) and LIR on subcutaneous tumors (ST) in mice. Methods: Sarcoma-180 cells (1×10 ) were implanted subcutaneously into the breast area of strain Cr1:CD-1-ICR (BR) female mice. Mice bearing ST were treated with Rh123 or LIR alone, or a combination of both, once a day for 3 successive days. Results: The best therapeutic effect was observed in the group treated with 7.5 mg Rh123 per kilogram of body weight, combined with 75 J/cm laser irradiation energy. The group's mortality rate, tumor control rate, mean survival time, and increase in lifespan within 120 days after treatment were 16.7%, 83.3%, 109.4 days,and 135.8%, respectively. The most inhibitory effect on tumor cells was found in the group treated with 15 mg/kg Rh and 90 J/cm laser irradiation. The biosyntheses of DNA, RNA, and protein in tumor cells of this group was obviously inhibited. Conclusion: PDT with the photosensitizer Rh123 and laser irradiation was therapeutically effective in treating subcutaneous tumors of mice. The tumor cells and the syntheses of DNA, RNA, and protein of the tumor cells in these PDT treated mice were obviously inhibited. |
本系統中英文摘要資訊取自各篇刊載內容。