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題 名 | The Role of the Oocyte and the Sperm in the Outcome after Intracytoplasmic Sperm Injection (ICSI) |
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作 者 | Horng,Shang-gwo; Wang,Hsin-shih; Wang,Mei-li; Huang,Hong-yuan; Lee,Chyi-long; Tsai,Chia-chang; Wang,Chia-woei; Huang,Yang-hua; Soong,Yung-kuei; | 書刊名 | Journal of Reproduction and Infertility |
卷 期 | 7:4 1998.12[民87.12] |
頁 次 | 頁157-163 |
分類號 | 417.125 |
關鍵詞 | Female age; Intracytoplasmic sperm injection; ICSI; Implantation rate; Pregnancy rate; Sperm parameters; |
語 文 | 英文(English) |
英文摘要 | Intracytoplasmic sperm injention(ICSI) had been widely used to improve fertilization in inferile couples with made factors and repeated in vitor ferilization (Ivf) failures. However, implantation and pregnancy rates are still low, especially in older women. The purpose of the present study is to explore the inftuence of oocyte and sperm qualities of both younger and older women on the outcome of ICSI. Two hundred and thirty eight cycles lf ICSI with either male factors or repeated IVF failures were reviewed. Female patients recruited for this study were divided into two age groups (<35 and 35>years). The fertlization, cleavage, implantation and pregnancy rates were andalyzed on the basis of sperm quality and female age. Fertlization and cleavage rates between the two age groups were not different. The older group showed poor implantation and pregnancy rates (implantation rate:15.7%and 5.7%, respectively, p=0.002;pregnancy rate;44.9%and 21.6%, respectively. p=0.002). In couples using seminal sperm, the outcome of ICSI was not different anong the different parameters. Pregnance rate is better in couples using epididymal sperms than the couples using testicular sperms (p=0.011, test ). Although the pregnancy rate is higher in couples using epididymal sperms, the sample size is so small that large sample size is needed for analysis. In all couples with male factors, the was a lower pregnanccy rate in women who were older than 35 years suggesting that female age, and more specifically. oocyte quality, might dominate in successful ICSI's. |
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