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題 名 | Expression of Estrogen Receptorsα and β in Human Osteoblasts: Identification of Exon-2 Deletion Variant of Estrogen Receptor β in Postmenopausal Women=甲型及乙型雌激素感受器在人類造骨細胞之表現:在停經後婦女發現缺損Exon-2之乙型雌激素感受器變異型 |
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作 者 | 陳芳萍; 許濤; 吳清華; 王文德; 王坤全; 鄧麗芬; | 書刊名 | 長庚醫學 |
卷 期 | 27:2 2004.02[民93.02] |
頁 次 | 頁107-115 |
分類號 | 417.224 |
關鍵詞 | 甲型雌激素感受器傳遞醋栗糖核酸; 乙型雌激素感受器傳遞醋栗糖核酸; 人類造骨細胞; 停經婦女; 缺損exon-2之乙型雌激素感受器; Human osteoblast; Postmenopausal women; ERαmRNA; ERβmRNA; Exon2 deletion of ERβmRNA; |
語 文 | 英文(English) |
中文摘要 | 背景:停經後骨質疏鬆症與雌激素缺乏有關。雌激素藉由雌激素感受器影響骨之代謝。如果雌激素的效應與雌激素感受器表現的量有關,雌激素感受器在停經後婦女的表現應會不同於以往使用造骨細胞群的研究。本篇研究在顯示取自停經後婦女和人類骨癌細胞系(MG63)之造骨細胞,其不同雌激素感受器傳遞醋栗糖核酸(ERmRNA)在分化中的表現。 方法:造骨細胞之培養取自停經後婦女和人類骨癌細胞系(MG63),在第5、10、15、20和25日造骨細胞培養中,以PT-PCR檢視造骨細胞中,甲型及乙型雌激感受器傳遞醋栗糖核酸(α and β ERmRNA)之表現。 結果:MG63造骨細胞在25天的培養中,乙型雌激素感受器傳遞醋栗糖核酸都呈現穩定且明顯之表現,而甲型雌激素感受器傳遞醋栗糖核酸則很難偵測到。由停經後婦女培養之造骨細胞,在25天的培養中都可看到甲型和乙型雌激素感受器傳遞醋栗糖核酸,但甲型雌激素感受器傳遞醋栗糖核酸之表現較乙型雌激素感受器傳遞醋栗糖核酸為強。在這16位停經後婦女之造骨細胞中,同時偵測到不同程度表現的缺損exon-2之乙型雌激素感受器傳遞醋栗糖醋栗糖核酸變異型。 結論:這些雌激素感受器傳遞醋栗糖核酸不同的表現,意謂著它們在骨的代謝中有不同的作用或互相影響。在造骨細胞培養中,乙型雌激素感受器傳遞醋栗糖核酸之於缺損exon-2之乙型雌激素感受器變異型、或甲型雌激素感受器傳遞醋栗糖核酸之於乙型雌激素感受器傳遞醋栗糖核酸,其不同比例之表現,可能與不同的骨質之狀況有關。缺損exon-2之乙型雌激素感受器變異型存在於停經後婦女是否會影響骨之生物特質,仍待研究確認。 |
英文摘要 | Background: Postmenopausal osteoporosis is associated with estrogen deficiency. Estrogens have effects on bone metabolism, which are mediated by estrogen receptors (ERs). If estrogen responsiveness is related to the ER expression level, ER expression in postmenopausal women should be different from previous studies using osteoblast lineage. We investigated the expression of variant isoforms of ER messenger ribonucleic acid (mRNA) in osteoblasts (OB) from postmenopausal women and a human osteosarcoma cell line, MG 63. Methods: Osteoblast cultures were prepared from the upper femur of postmenopausal patients or MG 63. For OB cultures at 5, 10, 15, 20, and 25 days, the expressions of ERα and β mRNA were examined using reverse transcriptase-poly-merase chain reaction. Results: In MG 63, ERβ mRNA was constantly and highly expressed during the 25-day culture, whereas ERα mRNA was barely detected. In the primary OB cells, both ERα andβ mRNA were transcribed during the 25-day culture, but expression of ERα mRNA was much stronger than that of ERβ mRNA. A splice variant form of ERβ mRNA that was missing the entire exon 2 (ERβ △2) was detected and heterogeneously expressed in OB cultures from 16 postmenopausal women. Conclusion: Differential expressions of these ER isoforms suggest that they may have different functions or that they interact with each other during bone metabolism. The different ratio of ERβ △2 mRNA or ERα to ERβ mRNA expression in osteoblast cultures may be related to different bone conditions. Whether the presence of ERβ △2 in postmenopausal women influences the biological properties of bone needs to be determined. |
本系統中英文摘要資訊取自各篇刊載內容。