頁籤選單縮合
題 名 | Quantitative Sensory Testing: Normative Values and Its Application in Diabetic Neuropathy |
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作 者 | Lin,Yea-huey; Chang,Yang-chyuan; Hung,Man-hui; Tai,Tong-yuan; Chen,Wei-hung; Yang,Chih-chao; Chen,Rong-chi; Hsieh,Sung-tsang; | 書刊名 | Acta Neurologica Taiwanica |
卷 期 | 7:3 1998.09[民87.09] |
頁 次 | 頁176-184 |
分類號 | 415.9 |
關鍵詞 | Quantitative sensory testing; Diabetic neuropathy; Polyneuropathy; Sensory thresholds; Normative value; Small-fiber neuropathy; |
語 文 | 英文(English) |
英文摘要 | Abnormal sensation (paresthesia) is one of the frequent complaints in patients with peripheral nerve disorders, in particular, diabetic neuropathy. The underlying pathophysiology includes dysfunctions or degeneration of myelinated and unmyelinated nerves. Functions of large myelinated sensory axons, which can be measured by nerve conduction studies, are responsible for proprioceptive sensation. Small myelinated and unmyelinated sensory axons (small-fibers) subserve nociceptive functions, the detection of pain and thermal stimuli. It is difficult to assess small fibers in clinical neurophysiology laboratory. The application of quantitative sensory testing, by measuring the thresholds to thermal and vibratory stimuli offers a convenient approach to quantify dysfunctions of small-diameter nerves. By establishing the normative values of quantitative sensory testing in Chinese, we evaluated its diagnostic potentials in diabetic neuropathy. Our results indicated that sensory thresholds in Chinese were similar to those reported elswhere under standard procedures of quantitative sensory testing, and small-fiber dysfunction was more frequent than large-fiber dysfunction in diabetic neuropathy. Up to 75% of patients with diabetic neuropathy had elevated thresholds to thermal stimulus in the lower limb. Fifty percent of these patients had elevated vibratory thresholds. Thepresent study documents the feasibility of performing quantitative sensory testing in evaluating diabetic neuropathy. The resluts indicate that dysfunction of small-diameter nerves should be considered in managing patients of diabetic neuropathy. |
本系統中英文摘要資訊取自各篇刊載內容。