頁籤選單縮合
題名 | Mycobacterial Lipoarabinomannan: An Extraordinary Lipoheteroglycan with Profound Physiological Effects |
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作者 | Chatterjee,Delphi; Khoo,Kay-hooi; | 書刊名 | 中央研究院生物化學研究所論文集 |
卷期 | 24 1998[民87.] |
頁次 | 頁233-240 |
分類號 | 369 |
關鍵詞 | CD1; Ethambutol; Lipoarabinomannan; Lipomannan; Mycobacteria; Phosphatidylinositol mannosides; Tuberculosis; |
語文 | 英文(English) |
英文摘要 | Detailed structural and functional studies over the last decade have led to current recognition of the mycobacterial lipoarabinomannan (LAM) as a phosphatidylinositol anchored lipoglycan with diverse biological activities. Fatty acylation has been demonstrated to be essential for LAM to maintain its functional integrity although the focus has largely been on the arabinan motifs and the terminal capping function. It has recently been shown that the mannose caps may be involved not only in attenuating host immune response. but also in mediating the binding of mycobacteria to and subsequent entry into macrophages. This may further be linked to an intracellular trafficking pathway through which LAM is thought to be presented by CDI to subsets of T-cells. The implication of LAM as major histocompatibility complex (MHC)-independent T-cell epitope and the ensuing immune response is an area of intensive studies. Another recent focus of research is the biosynthesis of arabinan which has been shown to be inhibitable by the anti-tuberculosis drug, ethambutol. The phenomenon of truncated LAM as synthesized by ethambutol resistant strains provides an invaluable handle for dissecting the array ofarabinosyltransferases involved, as well as generating much needed structural variants for further structural and functional studies. It is hoped that with more systematic investigations based on clinical isolates and human cell lines, the true significance of LAM in the immunopathogenesis of tuberculosis and leprosy can eventually be explained. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。