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題名 | Effects of Prokinetic Agents on Contractile Responses to Electrical Field Stimulation of Isolated Guinea Pig Trachea=促進腸蠕動藥物對天竺鼠氣管電刺激收縮反應之影響 |
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作者姓名(中文) | 鄒國英; 柯逢年; 簡志澔; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 98:8 1999.08[民88.08] |
頁次 | 頁567-572 |
分類號 | 418.24 |
關鍵詞 | 促進腸蠕動藥物; 天竺鼠; 氣管; 電刺激; 收縮; Trachea; Guinea pig; Metoclopramide; Cisapride; Prokinetic agent; Electrical field stimulation; |
語文 | 英文(English) |
英文摘要 | We investigated the effects of two prokinetic agents, metoclopramide and cisapride, on the contractile response of isolated guinea pig tracheal segments exposed to electrical field stimulation (EFS). Tracheal segments were suspended between two platinum electrodes in organ baths. Frequency-response curves were obtained by increasing the frequency of the stimuli on equilibrated tracheal segments, in a stepwise manner. Metoclopramide potentialed the EFS-induced contraction of the tracheal; the potentiation was more prominent at lower stimulation frequencies (≧ 10 Hz). Cisapride significantly inhibited the electrically stimulated contraction in trachea strips when the frequency of the stimulus was higher than 10 Hz. In the presence of both metoclopramide and cisapride, there was a potentiation of the contractile response at lower frequencies, and this potentiation was reduced when the frequency was higher than 10 Hz. These results demonstrate that metoclopramide enhances and cisapride reduces the airwaytonicity elicited by EFS in isolated guinea pig trachea segments. Further studies are needed to verify the effects of these prokinetic agents on EFS-induced contraction of isolated guinea pig trachea and to determine the mechanisms involved. |
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