頁籤選單縮合
題 名 | Pathogenesis of Ischemia Reperfusion Injury of the Kidney after Transient Renal Arterial Clamping in Rats=暫時性缺血及再灌注性鼠腎臟傷害之病理機轉 |
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作 者 | 于大維; 查岱龍; 張聖原; 馬正平; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 97:9 1998.09[民87.09] |
頁 次 | 頁606-613 |
分類號 | 415.74 |
關鍵詞 | 暫時性缺血; 再灌注性鼠腎臟傷害; Kidney; Ischemia; Reperfusion; Leukotriene; Thromboxane; Peroxidation; |
語 文 | 英文(English) |
英文摘要 | Renal function can be severely impaired through injuries sustained after both short and prolonged periods of complete ischemia. The magnitude of renal dysfunction resulting from these conditions and their reversibility depend on the duration of anoxia. In this study, we used a Sprague-Dawley rat model (5 to 7 rats in each group) to study the pathogenesis of short-term ischemia (30, 60, and 120 min) / reperfusion (2, 4, 24 h, 1 wk, and 3 wk) injury of the kidney under warm (room temperature) or cold (4℃) conditions. Ischemia was induced by clamping the renal artery. Changes in kidney weight, histopathology, concentrations of serum thromboxane and leukotriene, and tissue malonyldialdehyde (MDA) concentration, numbers of apoptotic bodies, and p53 expression in the kidney were compared with those of sham-operated rats. The results showed that the immediate increase in kidney weight due to inflammatory swelling was associated with simultaneous elevation of serum thromboxane and leukotriene levels. The changes in mediator levels were closely related to the duration of ischemia and temperature. Histologic structures were preserved better when renal artery clamping was done at 4℃. MDA peroxidation products from the ischemic tissue prominently increased 1 week following ischemia; this paralleled a secondary increase in leukotriene levels. Flow cytometric detection of p53 oncoprotein showed a marked increase at 1 week following ischemia, which was accompanied by the development of apoptotic bodies in ischemic tissues. These changes were also closely related to the ischemic time and temperature during ischemia. This animal model may be useful for future studies of the prevention of ischemia/reperfusion injury- of the kidney and for selection of effective antioxidants. |
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