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題名 | 出生體重非常低之早產兒的聽性腦幹反應=Auditory Brainstem Response in Premature Infants with Very Low Birthweight |
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作者姓名(中文) | 吳俊良; 王新臺; 趙文元; 陳勃旭; 李恒惠; | 書刊名 | 中華民國耳鼻喉科醫學會雜誌 |
卷期 | 33:6 1998.12[民87.12] |
頁次 | 頁41-46 |
分類號 | 417.517 |
關鍵詞 | 聽性腦幹反應; 早產兒; 潛時; Auditory brainstem response; Premature infant; Latency; |
語文 | 中文(Chinese) |
中文摘要 | 背景:新生兒之聽性腦幹反應各波的潛時(latency)及波間潛時(interpeak interval)會隨著年齡的增加而縮短,這種現象可歸因於:耳蝸的成熟、聽覺神經突觸間傳導致率的提昇及聽覺神經的髓鞘化。而此聽性腦幹反應成熟的速率,不但與先天的發展有關,外界環境的因素及嬰兒本身的健康情形也扮演著重要的角色。本研究主要即針對出生體重非常低(very low birth weight; VLBW)早產兒,觀察其聽性腦幹反應成熟速度是否異於一般足月產兒。 方法:收集出生體重低於1500公克早產兒,於矯正後年齡為六個月及十二個月時接受聽性腦幹反應檢查,與同年齡足月產兒作比較。矯正年齡為六個月大之早產兒有72名、足月產兒有10名;十二個月大之早產兒有65名、足月產兒有8名。排除第五波閾值大於25dB nHL之耳後,六個月大之實驗組有133耳、對照組有20耳;十二個月大之實驗組有123耳、對照組有15耳。分別比較兩組在75dB nHL click音刺激下之I、III、V波潛時及I-III、III-V、I-V波間潛時。 結果:在各波潛時方面,六個月大之早產兒的I波潛時為1.539 msce,比足月產兒之1.478 msec長(p=0.1381),而III波及V波潛時在兩組之間未達有意義的差異;十二個月大之早產兒的I波潛時為1.506 msec,比足月產兒之1.0448 msec要長(p<0.05),而 III波及V波潛時在兩組之間未有意義的差異。在波間潛時方面,六個月大之早產兒的I-III波間潛時為2.664 msec,比足月產兒之2.766 msec短(p<0.05),而III-V及I-V波間潛時都未達有意義的差異;十二個月大之早產兒 I-III波間潛時為2.542 msec,比足月產兒之2.609 msec短(p=0.059),且I-V波間潛時為4.663 msec,比足月產兒的4.768 msec短(p=0.05),III-V波間潛時在兩組間則未達有意義的差異。 結論:在出生體重非常低早產兒的聽性腦幹反應發現:I波潛時有延長,而I-III波間潛時有縮短的趨勢。I波潛時的延長可能與他們有較高的中耳炎發生率所造成的傳導性聽力障礙有關;I-III波間潛時的縮短可能與早產兒接觸外界環境較早,刺激其聽覺神經徑路的發 較快有關。 |
英文摘要 | Background: Premature infants with very low birthweight (VLBW) differ from the full term ones in the innate, environmental factors and the health. These differences probably result in a developmental change on auditory pathway. In this article, we compared the auditory brainstem response (ABR) of VLBW premature infants with those of the full term in order to auditory pathway between the two populations. Methods: ABR was performed on 72 six-month-old VLBW premature infants and 65 twelve-month-old premature infants. Ten six-month-old and eight twelve-month-old age-matched full term infants were tested as control group. Latency (L) and interpeak interval (IPI) of ABR were analyzed. Results: The L I in six-month-old VLBW premature infants was longer than that in the full term infants (1.539 msec vs 1.478 msec). The L I in twelve-month-old VLBW premature infants was also longer than that in the full term ones (1.506 msec vs 1.448 msec). There was no difference in L III and L V between the two groups. The IPI I-III in six-month-old VLBW premature infants was shorter than that in the full term infants (2.664 msec vs 2.766 msec). The IPI I-III in twelve-month-old VLBW premature infants (2.664 msec vs 2.766 msec). The IPI I-III in twelve-month-old VLBW premature infants was shorter than that in the full term ones (2.542 msec vs 2.609 msec). There was no difference in IPI III-V between the two groups. The IPI I-V in twelve-month-old VLBW premature infants was shorter than that in the full term infants (4.663 msec vs 4.768 msec), while no difference was noted in the six-month-old group. Conclusions: L I was longer and IPI I-III was shorter in VLBW premature infants than those in the full term infants. We considered that the prolongation of L I might be due to the higher incidence of otitis media in the VLBW premature infants. Longer extrauterine life duration of the VLBW premature infants might contribute to the shortness of IPI I-III. |
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