頁籤選單縮合
題 名 | Effect of Glycyrrhizic Acid, Glycyrrhetinic Acid and Cytochalasin B on Corneal Transport |
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作 者 | 廖嘉鴻; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:4 1998.08[民87.08] |
頁 次 | 頁205-213 |
分類號 | 418.1 |
關鍵詞 | Glycyrrhizic acid; Glycyrrhetinic acid; Cytochalasin B; Cornea; Transport; |
語 文 | 英文(English) |
英文摘要 | The purpose of this study was examined the mechanisms by which glycyr-rhizic acid (GZA), glycyrrhetinic acid (GA) and cytochalasin B influence the cornea and assessed their quantitative effects on intercellular transport. Examination of corneal diffusion with two radiolabeled compounds, glycerol (paracellular pathway) and estradiol(transcellular pathway) showed that the GZA (0.016mM) increased glycerol transport from an apparent permeability coefficient (P), 3.84±0.24 to 8.31±0.25×10 cm/sec after 5 hours incubation in GBR solution. In addition, GA also increased intercellular glycerol transport and decreased electrical resistance. However, the permeability of estradiol was not changed by these compounds. On the other hand, adding cytochalasin B with GZA or GA decreased the penetration of glycerol to control values (P=3.03±0.45, 4.40 ± 0.67, respectively). The interaction of GZA or GA with corneal tissues may open tight junctions with quickly recovery of membrane integrity after removing two compounds. |
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