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題名 | 傳統中藥與現代西藥交互作用之研究1.茵蔯蒿對乙醯胺基酚肝毒性的影響=Studies on the Interactions between Traditional "Chinese Medicine" and Modern "Western Drugs" Ⅰ.Influence of "In-Chen-How" (Artemisia Capillaris Thunb.) on the Hepatotoxicity of Acetaminophen |
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作者 | 楊竹茂; 黃秀琴; 林榮貴; | 書刊名 | 嘉南學報 |
卷期 | 24 1998.11[民87.11] |
頁次 | 頁150-163 |
分類號 | 414.5 |
關鍵詞 | 菌蔯蒿; 乙醯胺基酚; 相互作用; 麩胱甘冴; 急性肝細胞壞死; Artemisia capillaris thunb; Acetaminophen; Interaction; Acute hepatic necrosis; Glutathione; |
語文 | 中文(Chinese) |
中文摘要 | 本研究首先以高壓逆相液體層析法,配合螢光檢測器,分析多種茵蔯蒿濃縮製劑 中指標成分 scoparone 之含量,結果發現除了一種廠牌製劑每克含 0.25 毫克外, 大多市 售商品並未含,或僅含極微量之此一指標成分。 選用含指標成分最高的製劑為實驗藥物,連續五天灌食小白鼠及大白鼠,研究其對乙醯 胺基酚所誘發急性肝細胞壞死的影響。 經由測定動物之死亡率、 血清中麩氨草醋酸轉氨�t (SGOT) 及麩氨丙酮酸轉氨�t (SGPT) 之含量、 肝組織顯微切片、 及肝細胞中麩胱甘�� (glutathione) 之含量等指標結果顯示,茵蔯蒿之投予對乙醯胺基酚所誘發急性肝細胞壞死 不但無改善的效果,反而可能加重其肝細胞壞死的程度並加速其死亡。其原因可能與茵蔯蒿 加速乙醯胺基酚代謝成具有高度親核性的中間體 NAPQI,進而使肝細胞中麩胱甘�馧Q耗盡有 關。 由研究結果顯示「傳統中藥」併用「現代西藥」時,應該注意其可能產生的相互作用。 |
英文摘要 | The content of scoparone, an indicating component of "In-Chen-How", Artemisia capillaris Thunb. (AC), in 18 water-extracted and concentrated preparations was quantitatively analyzed by HPLC method. The results showed that few preparations contained this component, among them only one commercial product contained 0.25 mg/gm of it. The water-extract of AC with the highest content was selected as the pretreating drug in the study and was orally administered consecutively in mice and rats for 5 days before administration of acetaminophen. The influencing effects of AC on the metabolism and hepatotoxicity of acetaminophen were assessed by determining the mortalities, serum levels of GOT and GPT, microscopic examinations on hepatic tissue sections, and the glutatione contents in the liver homogenates, respectively. The results indicated that AC pretreatments not only failed to improve the hepatotoxicity induced by acetaminophen, byt also to deteriorate, i.e. increased mortality and serum levels of GOT and GPT, glutathione totally depleted, hepatic necrosis area enlarged. The reasons that leaded to the results may be attributed to the increased NAPOI level, which is a strong nucleophilic intermediate formed during the metabolism of acetaminophen. NAPOI has well known to bind intracellular glutathione irreversiblely and eventually deplete hepatic glutathione content. However, the change in NAPOI should be performed with the radioactive isotope-labelled method in the furture. Finally, the results of this study demonstrated that the possible interaction between traditional "chinese medicine" and the so-called "westerm drugs" should be concerned and noticed, especially for the people who often take both kinds of medicine. |
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