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題 名 | The Percutaneous Delivery of Prostaglandin E[feb5]and its Alkyl Esters by Microemulsions |
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作 者 | 何秀娥; 黃明權; 陳怜均; 夏安琪; 陳國棟; 江漢聲; 許明照; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:5 1998.10[民87.10] |
頁 次 | 頁257-266 |
分類號 | 418.1 |
關鍵詞 | Prostaglandin E[feb5]; Alkyl esters; Penetration; Cosolvent; Microemulsions; |
語 文 | 英文(English) |
英文摘要 | Two microemulsion systems were developed for percutaneous delivery of PGE1 and its alkyl esters through hairless mouse skin. Microemulsion I was based on Labrasol (HLB 14) as a nonionic surfactant and Plurol oleique (HLB 10) as a cosurfactant, whereas microemulsion Ⅱ employed Labrafac CM 10 (HLB 10) as a nonionic surfactant and Lauroglycol (HLB 4) as a cosurfactant. The addition of a variety of cosolvents into both microemulsion systems was found to cause insignificant effects on the formation of the microemulsions. The effect of a variety of cosolvents on the percutaneous penetration of PGE�� and its alkyl esters through hairless mouse skin was further examined. The penetration of all the prostaglandins examined from microemulsion Ⅱ was insignificant compared to microemulsion Ⅰ. The penetration rate of PGE�硬as higher than its alkyl esters from microemulsion Ⅰ with the same cosolvent. The enhancement of PGE1 percutaneous penetration from microemulsion Ⅰ was positively correlated with the hydroxyl number of polyhydric alcohols. For a given number of hydroxyl groups, an alcohol with an optimal carbon number enhanced the penetration rate to the greatest degree. However, the penetration rate of PGE�� from all formulations appeared inadequate for practical use. |
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