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題 名 | 選擇性血清素再吸收抑制劑=The Selective Serotonin Reuptake Inhibitors |
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作 者 | 李宇宙; 林信男; | 書刊名 | 臺灣精神醫學 |
卷 期 | 12:2 1998.06[民87.06] |
頁 次 | 頁3-13 |
分類號 | 418.214 |
關鍵詞 | 選擇性血清素再吸收抑制劑; 藥理學; 藥物動力學; 副作用; Selective serotonin reuptake inhibitors; Pharmacolgy; Pharmarcokinetics; Adverse effect; |
語 文 | 中文(Chinese) |
中文摘要 | 選擇性血清素再吸收抑制劑(SSRIs)已經被證實為有效而安全的第二代抗鬱劑,透過改變5-HT神經傳遞的作用,對於憂鬱症、強迫症、焦慮症等常見的多種精神疾病,都有明顯的療效。一般相信不同的SSRIs對於各種適應症的臨床療效沒有明顯的區別。不過由於化學結構與藥物動力學的差異,在副作用和併用其它藥物治療的交互作用上,不同屬性的個案必須有不同的考量。本文以文獻回顧針對國內常用的fluoxetine, fluvoxamine, paroxetine, sertraline等四種藥物的做比較進行扼要的回顧, 以供國內精神科從事臨床工作與研究的參考。SSRIs 最常出現的副作用為噁心及頭痛,都達20%以上。各種不同的藥物由於仍然涉及和1,2腎腺素、乙醯膽鹼、多巴胺等受體不等程度的親和性,以及半衰期的互異,臨床副作用的表現也有所不同。在代謝過程中經由cytochrome P450不同酵素的交互抑制作用,和其它藥物併用時對藥物動力學也會有影響。臨床處理時宜謹慎選擇不同種類的SSRI藥物,尤其是伴有身體疾病或老年患者。精神症狀學與病理學和次級受體的關係應該是今後藥物治療研究的重點之一。 |
英文摘要 | Selective serotonin reuptake inhibitors are effective and tolerable psychotropic medications not only in the treatment of depression but also in a wide range of other minor mental disorders. The therapeutic effect of these agents is mediated by the facilitation of 5-HT neurotransmission. Studies have shown that SSRIs are equally efficacious except in the treatment of hospitalized depressive patients. In addition, differences in the pharmacodynamic and pharmacokinetic profiles of these agents raise the question of whether some patient populations may benefit more from one SSRI than another, especially in terms of adverse effects. This review examines the literature on the comparison of the available SSRIs in an attempt to draw inferences about the relative efficacy of these agents in various patient populations and settings. Nausea and headache were the most frequent side effects, and were reported by more than 20% of all patients receiving SSRI treatment. Although the affinity of SSRIs for receptors such as muscarinic and 5 HT subtype receptors seems to be low, related adverse effects are not uncommon and can be intolerable. Recently, the role of cytochrome P450 enzyme in the metabolism of antidepressants has been proposed to account for the inter-individual variations in response and adverse effects of different SSRIs. Particular caution is warranted when using SSRIs with a high inhibitor potency or a narrow therapeutic index and when combined with other medications. |
本系統中英文摘要資訊取自各篇刊載內容。