頁籤選單縮合
題名 | Synthesis and Antibacterial Activity of Penicillin Derivatives Containing a (N[feb5]-Subatituted-6-Fluoro-4-Oxoquinolin-3-yl) Carbonyl Moiety |
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作者姓名(中文) | 鄒臺黎; 湯尚道; 張淑玲; 吳靜然; 譚立政; 吳清水; | 書刊名 | 中華藥學雜誌 |
卷期 | 50:6 1998.12[民87.12] |
頁次 | 頁369-383 |
分類號 | 418.281 |
關鍵詞 | Fluoroquinolonyl-penicillins; Synthesis; Antibacterial activity; |
語文 | 英文(English) |
英文摘要 | A series of ampicillin and amoxicillin derivatives containing a N��-substituted-(6-fluoro-1, 4-dihydro-4-oxoquinolin-3-yl) carbonyl moiety at the α -amino group were prepared and their antibacterial activities were evaluated. These derivatives displayed a broad spectrum of antibacterial activity against Gram (+) and Gram (-) bacteria. In comparison with the original antibiotics, some of the derivatives were more active against Pseudomonas aeruginosa, Streptococcus pyogenes, and β -lactamase producing Staphylococcus aureus strains. The MICs ranged from 3.2 to 13 μ g/mL for P. aeruginosa and from 0.0062 to 0.05 μ g/mL for St. pyogenes. However, their antibacterial activities decrease when the N-1 position was replaced with alkyl substituents. |
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