頁籤選單縮合
題 名 | Epstein-Barr Virus DNA Polymerase Inhibitors from Chinese Herbs: Use of Preliminary Screening, Physicochemical Properties and Taxonomy for New Lead Compounds Generation |
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作 者 | 連榮吉; 裴黃花; 任士君; 陳瓊雪; 林美珠; 邱卓凡; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:4 1998.08[民87.08] |
頁 次 | 頁233-247 |
分類號 | 418.1 |
關鍵詞 | Antiviral agents; Epstein-barr virus DNA polymerase; EBVDP; Physicochemical properties; α,β-unsaturated lactones; Coptisine chloride; Costunolide; Daidzein; Taxonomy; New lead compounds generation; |
語 文 | 英文(English) |
英文摘要 | A paradigm of combining preliminary screening data, SAR, functional group and taxonomical analyses has been proposed for new lead compounds generation. Based on the screening data of 38 natural products, a quaternary ammonium derivative (coptisine chloride), a sesquiterpene with and α,β-unsaturated lactone function and an isoflavonoid (daidzein) have been found to be most active. Based on the analyses of overall structures, physicochemical properties and taxonomical relationships, 47 related compounds and six families of plants are suggested for further investigation. Due to the inherent biodiversity, nature may still be the best source for new drug discovery. |
本系統中英文摘要資訊取自各篇刊載內容。