頁籤選單縮合
題名 | 甲氧基護谷與2,4-地除草劑誘發大鼠子代外觀、細部骨骼及內臟異常性評估=The Effects of the Herbicide Chlormethoxynil and 2,4-D on External, Skeletal and Visceral Anomalies of Fetuses in Rats |
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作者 | 呂水淵; 王順成; Lu, Shui-yuan; Wang, Shun-cheng; |
期刊 | 中華民國獸醫學會雜誌 |
出版日期 | 19980300 |
卷期 | 24:1 1998.03[民87.03] |
頁次 | 頁29-41 |
分類號 | 433.85 |
語文 | chi |
關鍵詞 | 甲氧基護谷; 2,4-地; 外觀畸形; 骨骼畸形; 內臟異常; Clormethoxynil; 2,4-D; External malformation; Skeletal abnormality; Visceral abnormality; |
中文摘要 | 以胃管投藥法探討甲氧基護谷(chlormethoxynil)及2,4-地(2,4-D)兩種本省常用 除草劑其潛在致子鼠外觀、細部骨骼與內臟異常之影響。試驗結果顯示,兩藥劑在測試劑量 下,均未引起子鼠外觀畸形(external malformation)。在誘發子鼠細部骨骼異常(skeletal variation and malformation)方面,甲氧基護谷藥劑可造成子鼠頭顱窗門張大、胸骨小於 6根、胸骨異常或發育不全、肋骨融合、波浪狀肋骨或肋骨異常及啞鈴狀胸椎中心等症狀; 2,4-地藥劑使子鼠形成頭顱窗門張大、胸骨異常或發育不全、波浪狀肋骨或肋骨異常及啞鈴 狀胸椎中心等現象。就子鼠之內臟異常(visceral variation and malformation)而言,甲 氧基護谷及2,4-地均可造成氣管不規則、腎臟左右大小不一、腦積水與腦室異常及大腦兩側 大小不一及咽裂等異常;此外,甲氧基護谷藥劑另可產生胸腺分裂。兩藥劑所造成之子鼠畸 形均屬輕度畸形性。 |
英文摘要 | This study evaluated the teratologic effects as external, visceral, and skeletal examinations of fetus in rats. The test was administered by a gavage with the chlormethoxynil and 2,4-D. Experimental/Analysis results did not detect any external malformations in the two herbicides. However, these herbicide-breated rats contained common skeletal anomalies and variations such as large open fontanelle, number of the sternal < 6, hypoplastic or split sternal, fused ribs, wavy ribs, dumbell-shaped thoracic center. In addition, among the visceral defects in the herbicides included irregular trachea, side-weighed kidney, enlarged brain ventricles, and cleft pharynx. Split thymus was found only in chlomethoxynil. Based on the results presented herein, we can conclude that chlormethoxynil and 2,4-D are weakly teratogenic agents in rats. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。