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題名 | Comparison of Safety and Efficacy of Erysipelas Inactivated and Attenuated Vaccines in Mice and Pigs=豬丹毒不活化菌苗與弱毒活菌苗之安全與免疫效力 |
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作者 | 陳清; 呂清泉; 林旭志; 郭乃維; 詹益波; Chen, Ching; Lu, Ching-chuan; Lin, Shiuh-chih; Kuo, Nae-wei; Chan, I-po; |
期刊 | 中華民國獸醫學會雜誌 |
出版日期 | 19980600 |
卷期 | 24:2 1998.06[民87.06] |
頁次 | 頁73-81 |
分類號 | 437.245 |
語文 | eng |
關鍵詞 | 豬丹毒; 不活化菌苗; 弱毒活菌苗; 免疫效力; Erysipelas; Inactivated bacterin; Attenuated vaccine; Immunity potency; |
中文摘要 | 試製之豬丹毒不活化菌苗與弱毒活菌苗,以小白鼠及豬隻作安全及免疫效力試驗之 結果,得知兩者對供試動物均無不良之接種反應。小白鼠即使注射10倍豬免疫劑量之弱毒活 菌苗亦無任何不良反應,而接種 1.4X10 �� CFU/Mouse/SC 即可耐過 100MLD 之攻擊。另一 方面不活化菌苗, 其安全性雖甚佳,但免疫效力要達耐過 100 MLD 之玟垂,則需 3X10 �� CFU/Mouse/SC 以上。4 頭豬隻免疫接種弱毒活菌苗 2 週後血青對豬丹毒強毒株 (1a) 發育 凝集抗體價 (G A titer) 達 1:32,攻擊後 2 週其抗體價亦無明顯改變。 但 6 頭豬隻接 種不活化菌苗 2 週後其血清中發育凝集抗體價均為 1:8,攻擊後 2 週則達 1:128 -1:512 不等。此等高抗體價顯然是攻擊耐過之免疫反應。由試驗結果顯示,弱毒活菌苗效果優於不 活化菌苗。 |
英文摘要 | Mice and pigs were used to test the safety and efficacy of mono-and poly-valent inactivated vaccines and mono-valent attenuated vaccine of erysipelas. The results showed noside reactions on either experimental animals, even when 10 times doses for pigs were used inmice. When the mice were immunized, subcutaneously, with 1.4 X 10 �� CFU of attenuated vaccine they resisted to the challenge of 100 MLD of a virulent Erysipelothrix rhusiopathiae (Er).Although the inactivated vaccine is very safe, a vaccin ation dose of 3 X 10 �� CFU was required for the protection from the 100 MLD challenge. On the other hand, the growth agglutination (GA)tilers of four pigs were 1: 32 when the sera were collected at two weeks after vaccination using attenuated vaccine. In addition, no distinct changes in the GA liters were found at two weeksafter challenge (4 weeks after vaccination). However, the GA titers were 1:8 for other 6 pigs when the sera were tested at 2 weeks after vaccination with inactivated vaccine. This titers increased to 1:128 to 1:512 when the sera were tested at two weeks after challenge.Theseincreased titers were apparently due to the exposure of pigs to challenge Er. The results indicated that the efficacy of the attenuated yaccine is better than that of the inactivated bacterin. |
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