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題名 | Absorption and Disposition Kinetics of Trimethoprim Following Intramuscular Injection in Rabbits=Trimethoprim在家兔體內的動態 |
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作者 | 許如玉; 許興智; 陳憲弘; 王一邦; 陳素容; | 書刊名 | 藥物食品分析 |
卷期 | 6:2 1998.06[民87.06] |
頁次 | 頁485-494 |
分類號 | 418.635 |
關鍵詞 | 藥物動力學; 肌肉注射; 靜脈注射; 生體可用率; 家兔; Trimethoprim; Pharmacokinetics; I.m.; I.v.; Bioavailability; Rabbit; |
語文 | 英文(English) |
中文摘要 | 本文報告以九隻紐西蘭雄性白兔(2.67±0.16 kg)探討抗菌藥Trimethoprim(TMP) 經靜脈及肌肉注射後之體內動態,作為開發TMP肌肉注射劑型之基礎資訊。以TMP乳酸 鹽溶液(TMPL)15.3 mg / kg劑量靜脈注射後,其血中TMP之經時變化可用二室體模式加 以歸納(C=Ae + Be )。其藥物動力學速率常數及動力學參數分別為λ : 6.72±2.37 h , λ : 0.898±0.24 h ,k : 1.81±0.24 h ,k : 2.48±1.25 h ,k : 3.34±1.31 h ,V : 1.87 ±0.21 l, V : 1.39±0.91,Cl: 1.25±0.12 l/h/kg.。肌肉注射TMPL及TMP glycofurol溶液 (TMPG)後,TMP皆完全吸收(F=1.0)。然而TMPL注射後TMP之吸收遠比注射TMPG 快速。其平均吸收時間各為TMPL:0.4±0.1 h,而TMPG:1.0±0.1 h。注射TMPL於肌肉 後之C 為8.91±1.48 mg / l 也比注射 TMPG 後之C 5.97±0.88 mg/l 為高。TMP在家兔 血球內之分布率各為 0.388±0.015(靜注)和 0.279±0.019 (肌注) 。 |
英文摘要 | The absorption and disposition kinetics of an antimicrobial agent, trimethoprim (TMP) were investigated using New Zealand white male rabbits. The blood and plasma concentration-time curves obtained subsequent to the intravenous administration of trimethoprim lactate solution (TMP 15.3 mg/kg body weight) were fitted to a two-compartment body model (C=Ae +Be ). The rate constants of TMP based on the blood data wereλ : 6.72±2.37 h (mean ±SD);λ : 0.898± 0.149 h ; k : 1.81±0.24 h ; k : 2.48±1.25 h ; k : 3.34±1.31 h and the volumes of distribution were V : 1.87±0.21 l and V : 1.39±0.91 (2.67±0.16 kg body weight) . The body clearance of TMP was 1.25±0.12 l/h/kg. The availability of TMP in lactate (TMPL) and in glycofurol (TMPG) solutions administered to the values lateralis muscle was equivalent to that of the intravenous administration at the same dosage. However, the mean absorption time (MAT) of TMP from muscle was significantly shorter with TMPL solution (0.4±0.1 h) than with TMPG solution (1.0±0.1 h). The mean C obtained with TMPL (8.91±1.48 mg/l) was higher than that obtained with TMPG (5.97±0.88 mg/l). The fraction of TMP in the rabbit blood cells averaged 0.388±0.015 (i.v.) and 0.279±0.019 (i.m.). .). |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。