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題名 | 維生素K[feb0]單獨或併用游離輻射對人類肝癌細胞的影響=The Effects of Menadione Alone or Combined with Ionizing Radiation on Human Hepatoma Cells |
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作 者 | 黃正仲; 陳惠娥; 曾婉芳; 林冠如; 鄧文炳; 林芳仁; | 書刊名 | 放射治療與腫瘤學 |
卷期 | 5:2 1998.06[民87.06] |
頁次 | 頁101-109 |
分類號 | 416.36 |
關鍵詞 | 維生素K[feb0]; Hep3B肝癌細胞; 合併治療; 協同作用; Menadione; Hep3B hepatoma cell; Combined treatment; Synergistic effect; |
語文 | 中文(Chinese) |
中文摘要 | 目的:本研究的目的在探討維生素K□(menadione)單獨或併用游離輻射對於人類 肝癌Hep3B細胞之殺傷作用。 材料與方法:本實驗分別探討Hep3B細胞以維生素K□,游離輻射單獨處理或合併處理 時之存活曲線,合併處理之方式如下:先給予35μM維生素K□三小時再輻射照射;或先輻射 照射再給予維生素K□;或在維生素K□存在下,同時給予輻射照射。 結果:研究結果發現維生素K□對於Hep3B細胞之生長有抑制作用,其使50%細胞死亡之 濃度(IC□)約為60μM。以10-100μM維生素K□處理Hep3B細胞三小時後,細胞內還原態 麩胱甘□顯著降低。以2Gy以上劑量與維生素K□合併處理時,Hep3B之存活分率大部份都 降至15%以下,顯著增加癌細胞死亡的效果。 結論:以游離輻射和維生素K□合併處理細胞時,以"先照射後給予維生素K□"或者"維 生素K□存在的同時給予輻射照射"兩種情況最好,具有協同殺傷癌細胞的作用 (synergism)。至於"先給予維生素K□再輻射照射",除3Gy外,其餘都只有加成作用。此 種治療順序的差別導致癌細胞死亡率的差異,可能有助於維生素K□在合併治療上的應用。 |
英文摘要 | Purpose: To study the killing effects of menadione alone or combined with ionizing radiation on human hepatoma Hep3B cell. Materials and Methods: log-phase Hep3B cells were treated with menadione, ionizing radiation or the combination of both agents. Three protocols for combined treatments : first, cells were pre-treated with 35 μM menadione for 3 hours then irradiated; second, cells were irradiated followed by the menadione treatment: third, cells were concurrently treated with both agents. Results: The menadione inhibited the Hep3B tumor cells growth. the IC□ was around 60 μM. The intracellular reduced glutathione was significantly decreased after menadione treatment for 3 hours. After combined treatment most surviving fractions were less than 15%. Conclusions: Both 'pre-irradiation followed by menadione' and 'concurrent treatment' have synergistic effect. However, 'pre-treatment of menadione followed by irradiation' only has the addition effect. This finding may be useful for clinical application of menadione when combined with ionizing radiation to treat cancers. |
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