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頁籤選單縮合
題名 | 糙薏仁對致敏鼠過敏反應之影響=Effect of Dehulled Adlay on Allergic Responses of Sensitized Mice |
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作者 | 徐明麗; 林璧鳳; 江文章; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 23:2 1998.05[民87.05] |
頁次 | 頁161-170 |
分類號 | 411.3 |
關鍵詞 | 糙薏仁; 免疫球蛋白; 過敏; Dehulled adlay; Immunoglobulin; Allergy; |
語文 | 中文(Chinese) |
中文摘要 | 本研究的目的乃以致敏動物的模式,探討糙薏仁對過敏疾病的影響。本實驗以6週齡BALB/c雄性小鼠為對象,分別餵食含0%(對照組)、20%、90%糙薏仁粉飼料6週後,以卵蛋白(ovalbumin, OVA)作為抗原,加於佐劑A1(OH)3中,以腹腔注射分別進行二次致敏,使小鼠產生過敏反應後,繼續飼養2週後犧牲,測各組織重量。實驗中除了觀察小鼠外觀外,同時也測定小鼠體重變化、攝食量並且眼窩抽血測量過敏抗體IgE和IgG2a,以瞭解糙薏仁對致敏鼠過敏反應之影響。結果顯示,無論是20%糙薏仁組或90%糙薏仁組,其小鼠之體重、攝食量與對照組相較,統計上無顯著性差異。在臟器方面,除肺臟有顯著差異外(P<0.05),其他各臟器相對重量與對照組相較,統計上無顯著性差異。在血清抗體方面,20%糙薏仁組小鼠血清中抗OVA特異性IgE抗體顯著低於對照組(P<0.05),而血清中抗OVA特異性IgG2a顯著高於對照組(P<0.05);90%糙薏仁組血清中抗OVA特異性IgE抗體顯著高於對照粗,而IgG2a與對照組相較,則無顯著差異(P>0.05),但在動物外觀上,發現與對照組比較,毛色很明顯的偏黃,無光澤、不平順的情形。由此致敏動物模式中的過敏抗體結果推測,20%糙薏仁組可能有改善過敏的效果,而90%糙薏仁組則無。 |
英文摘要 | To investigate the effect of dietary dehulled adlay on allergic responses of sensitized animals, BALB/c mice aged six weeks were fed three different diets containing 0% (control group), 20% and 90% dehulled adlay, respectively. After six weeks' feeding period, the mice were sensitized twice by intraperitoneal injection of ovalbumin and aluminum hydroxide, and then sacrificed two weeks later. During the feeding period, the apparent change of the mice, the body weight change and total feed intake were recorded. The mice were bled retroorbitally for serum ovalbumin-specific IgE and IgG2a antibodies determination. The results showed that there were no significant differences in the body weight, total feed intake and the relative tissue weight (except lung) of the mice (P>0.05) among the three groups. Significantly lower serum anti-OVA IgE level and higher IgG2a level (P<0.05) were noted in the 20% adlay group compared to those of the control group. Significantly higher serum anti-OVA IgE level was noted in the 90% adlay group compared to those of the control group. However, there was no significant difference in the serum anti-OVA IgG2a between the 90% adlay group and control group. In addition, the apparent change of mice was noted in the 90% adlay group. The hair became more yellowish, less lustrous and smoothless. The significantly lower serum anti-OVA IgE and higher IgG2a antibody productions in the OVA-sensitized mice fed 20% adlay diet suggesting that 20% adlay group might improve allergic effect, but not the 90% adlay diet. |
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