查詢結果分析
相關文獻
- Effect of Quinapril Therapy on Blood Pressure and Serotonin Change in Patients with Mild to Moderate Hypertension
- 選擇性血清素再吸收抑制劑
- Fluoxetine--濫用藥品?
- Different Effects of 5-HT Receptor Agonists on Operant Response in Rats under DRL 10-s and DRL 30-s Schedules
- 血清素(Serotonin)症候群
- 新一代抗憂鬱藥物--選擇性血清素再回收抑制劑(Selective Serotonin Reuptake Inhibitors, SSRIs)之系統性回顧(Systematic Review)及選擇指引
- 精神疾病藥物治療病案討論(6)--選擇性血清素再吸收抑制藥於治療創傷後壓力症之角色
- 血清素第二型受體在憂鬱症及其治療所扮演的角色
- SPECT Imaging Agents for Dopamine and Serotonin Transporters in the Brain
- 腎元數目與本態性高血壓
頁籤選單縮合
題 名 | Effect of Quinapril Therapy on Blood Pressure and Serotonin Change in Patients with Mild to Moderate Hypertension=Quinapril對輕、中度高血壓患者血壓及血清素的變化 |
---|---|
作 者 | 黃金隆; 陳甫州; 陳穎從; 丁紀臺; | 書刊名 | 中華醫學雜誌 |
卷 期 | 58:5 1996.11[民85.11] |
頁 次 | 頁329-334 |
分類號 | 415.31 |
關鍵詞 | 血管張力素轉換酶抑制劑; 本態性高血壓; 血清素; Angiotensin converting enzyme inhibitor; ACEI; Hypertension; Quinapril; Serotonin; |
語 文 | 英文(English) |
中文摘要 | 背景 過去許多研究顯示血清素可經由其接受器產生血管收縮作用而 使血壓上升,血管張力素可經由血小板凝集促使血小板分泌更多的血管素,本 研究使用Quinapril於中輕度的高血壓患者探索其血中血清素的變化。 方法 本研究共有二十二高血壓患者(十名男性,十二名女性)沒有其它重大 內科疾病和次發性高血壓原因,這些高血壓患者經兩個星期安慰劑之後,開始 給Quinapril每天給10毫克,然後依血壓的變化加以調整直到正常範圍為止 (< 140/90 mmHg)。每位患者在安靜的環境中平躺一小時量血壓,然後再抽血檢查 血中的血清素,同樣的步驟八個星期後再作壹遍,去看其血中血清素的變化。 結果 血壓在經兩個星期藥物治療後有明顯的下降,由原來174/107 mmHg降 至134/87 mmHg,在這二十二高血壓患者有十四位經Quinapril治療後下降至正 常範圍,血漿中的血清素亦有差異的下降,由原來4.69 ng/ml降至2.89 ng/ml,p < 0.05,血壓的下降與血漿中血清素的變化間的相關係數為r = 0.019。 結論 本研究顯示Quinapril是一種有效的抗高血壓藥物,而且下降血漿中的血 清素。然而血壓的下降與血漿中血清素的變化沒有相關,這兩種作用可能是經 由不同的機轉。 |
英文摘要 | Background. Previous studies have shown that serotonin plays an important role in hypertension because of its vasoconstrictive effect, mediated through serotonergic receptors. Angiotensin-II is a potent vasopressor which facilitates the aggregation of platelets, subsequently releases serotonin. Because quinapril is an angiotensin-converting enzyme inhibitor and could result in a decrease of angiotensin-II, Quinapril was used to treat patients with mild or moderate hypertension in order to observe the change of plasma serotonin. Methods. Twenty-two patients, (10 males, 12 females, mean age 45 yrs) without other major medical diseases and secondary causes of hypertension, were selected for this study. High performance liquid chromatography (HPLC) with electrochemical detection was used to detect the plasma serotonin. These patients were given placebos for two weeks before the first dose of quinapril (5 mg). Thereafter, the dosage was adjusted according to the response of blood pressure to a desired value (BP < 140/90 mmHg). At about 14:00 hours on the first day, after the patient had rested for an hour and was in a quiet condition, blood was drawn by venipuncture with heparin as anti coagulant; the plasma serotonin concentration was determined for the baseline value. The plasma serotonin level was rechecked eight weeks later. Results. It was found that systolic blood pressure began to decrease significantly two weeks after quinapril therapy, and then reached a constant state. Blood pressure decreased from 174/107 mmHg to 134/87 mmHg. Among these 22 patients, there were 14 (65%) whose blood pressure reduced to a normal range. Plasma serotonin also decreased significantly from 4.69 +/- 3.67 ng/ ml to 2.89 +/- 2.64 ng/ml (p < 0.05). According to this data,15 in 22 patients (68%) had reduction of plasma serotonin. There was little correlation between change in blood pressure and change of plasma serotonin; the correlation coefficiency is only 0.019. Conclusions. This study shows that quinapril has an antihypertensive property and serotonin-lowering effect. Since there was no correlation between the change of serotonin and blood pressure, these two actions of quinapril might have been mediated through different mechanisms. |
本系統中英文摘要資訊取自各篇刊載內容。