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- Factors Affecting Progenitor Cell Yields Using Three Tandem Leukaphereses in Previously Treated Malignancies
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題 名 | Factors Affecting Progenitor Cell Yields Using Three Tandem Leukaphereses in Previously Treated Malignancies=影響曾治療之癌症病患連續3次周邊血前驅細胞收集量之因素 |
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作 者 | 林炯熙; 曾成槐; 胡惠宇; 雍建輝; | 書刊名 | 中華醫學雜誌 |
卷 期 | 61:12 1998.12[民87.12] |
頁 次 | 頁700-707 |
分類號 | 414.7 |
關鍵詞 | 白血球分離術; 周邊血前驅細胞; 顆粒性白血球群刺激因子; CD34狇; Granulocyte-colony-stimulating factor; Leukapheresis; Peripheral blood progenitor cell; |
語 文 | 英文(English) |
中文摘要 | 背景對於各種癌症接受骨髓摧毀性治療者,因動員周邊血前驅細胞重建造血較快 ,而漸取代骨髓移植。關於影響連續3次周邊血前驅細胞收集總量之因素,目前罕有報告。 方法本研究分析121位曾接受治療之癌症病人,影響連續3次周邊血前驅細胞收集總量之 因素。其中有36位非何杰金氏淋巴瘤、2位何杰金氏淋巴瘤、4位多發性骨髓瘤、44位 急性白血病、20位乳癌及15位其它硬瘤。動員周邊血前驅細胞之方法有三,分別為:僅 以顆粒性白血球群刺激因子( G-CSF )動員者15例;以傳統劑量化學治療加上 G-CSF 動 員者70例;以高劑量化學治療加上 G-CSF 動員者36例。 每位病人連續3次周邊血前驅 細胞收集總量是以單核細胞、CD34 �孜妝妦茩M及 CFU-GM 評估。 所分析之因素包括:年齡 、性別、診斷、骨髓侵犯史、放射治療史、化學治療次數及動員方法等。分別利用線形回歸 及邏輯回歸作單變數及多變數分析。 結果單變數分析發現,急性白血病、骨髓曾有癌細胞侵犯、化學治療次數多及以高劑量化學 治療動員者, 均收集到較少之 CD34 �孜妝妦茩M。 多變數分析顯示:第二組之單核細胞( p=0.039 )、 CFU-GM ( p=0.002 )及 CD34 �孜妝妦茩M( p=0.011 )收集量比第三組多 ; 影響 CD34 �孜妝妦茩M( p =0.016 )與 CFU-GM 收集量( p=0.017 )之共同有利因素 為化學治療次數少。 結論化學治療次數多對於周邊血前驅細胞之收集量有不良影響。由此研究看來,對於曾多次 接受化學治療而骨髓造血能力有限的病人, 動員傳統劑量化學治療加上 G-CSF 為較佳之方 法。周邊血前驅細胞之收集應於癌細胞最少時盡早施行,以避免化學治療毒性之累積。 |
英文摘要 | Background. Mobilized peripheral blood progenitor cells (PBPCs) have increasingly been used to replace autologous bone marrow to allow faster hematopoietic reconstitution after myeloablative therapy in various malignancies. There is a paucity of data concerning factors that affect the total yield of three tandem leukaphereses. Methods. Factors affecting the yield of PBPCs were analyzed in a series of 121 consecutive patients including 36 with non-Hodgkin's lymphoma, two with Hodgkin's disease, four with multiple myeloma, 44 with acute leukemia, 20 with breast cancer and 15 with other solid tumors. PBPCs were mobilized using granulocyte-colony-stimulating factor (G-CSF) alone (group I, n=15), or after conventional-dose (group Ⅱ, n=70) or high-dose (group Ⅲ, n=36 ) chemotherapy followed by G-CSF. The total yield of three tandem PBPC collections for each patient was assessed by the number of mononuclear cells (MNCs), CD34 �� cells and colony-forming units of granulocyte macrophages (CFU-GM). The factors evaluated included age, sex, diagnosis, history of marrow involvement, previous radiotherapy, the number of prior chemotherapy cycles and mobilization method. The two-sample t-test and logistic regression analysis were performed for univariate and multivariate analysis, respectively. Results. With univariate analysis, a diagnosis of acute leukemia, positive history of bone marrow involvement, more chemotherapy cycles and mobilization with high-dose chemotherapy adversely affected the yields of CD34 �� cells. By multivariate analysis, Group Ⅱ had higher yields of MNCs (p=0.039), CFU-GM (p=0.002) and CD34 �� cells (p=0.011) than Group Ⅲ. Fewer cycles of prior chemotherapy is the common favorable factor for the yields of both CD34 �� cells (p=0.016) and CFU-GM (p=0.017). Conclusions. The number of prior chemotherapy cycles adversely affects progenitor cell yield. Conventional-dose chemotherapy followed by G-CSF seems to be the mobilization method of choice for heavily pretreated cancer patients with limited bone marrow reserve. PBPCs should be harvested early, when the tumor burden is less, to avoid cumulative marrow toxicity from chemotherapy. |
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