查詢結果分析
相關文獻
- Central Catecholaminergic Systems: Functions of Methyldopa in Cardiovascular Control
- The Cardiovascular Effect of Ketamine (A Brief Review)
- Assessing the Potential Bioequivalence Requirement for Oral Immediate Release Dosage form: Post Approval Changes for Cardiovascular Drugs
- Circadian Blood Pressure Rhythm in Diabetic Patients with Caridovascular Autonomic Neuropathy
- Myocardial Effects of beta-Agonist Stimulation in Rats with Chronic Left Ventricular Dysfunction Treated with an Angiotensin-Converting Enzyme Inhibitor
- 血管收縮素接受器阻斷劑之臨床應用
- 犬貓呼吸器及心臟血管系統疾病
- Biopsychosocial Aspects of Stress Coping
- 心臟血管系統之進階性急救處置
- Applying Normal forms Method to Power System Analysis
頁籤選單縮合
題 名 | Central Catecholaminergic Systems: Functions of Methyldopa in Cardiovascular Control=中樞兒茶酚胺系統: 甲基二羥苯基丙基酸之心臟血管控制作用 |
---|---|
作 者 | 童吉士; 曾清俊; | 書刊名 | 醫學研究 |
卷 期 | 11: 附輯1 民80.04 |
頁 次 | 頁43-54 |
分類號 | 418.22 |
關鍵詞 | 二羥; 中樞兒; 心臟; 丙基酸; 甲基; 血管; 作用; 系統; 苯基; 茶酚胺; 控制; |
語 文 | 英文(English) |
中文摘要 | 腦幹中不同區域之神經訊息傳遞活動對於中樞心臟血管之控制角色具有重要的調節意義。倘若藥物影響這些區域的神經活性,將有可能引發身體循環變化,例如甲基二羥苯基丙基酸即為範例。根據我們以往研究腦幹中三處區域,獨立束,腹側延腦區和藍斑核位置的經驗,我們將於本篇文章當中簡要歸納以往的研究心得分為三階段,探討中樞腎上腺性神經作用和甲基二羥苯基丙基酸的降壓機轉關係。每一階段當中,我們將予討論實驗假設建立,結果判斷分析,以及當時未能完全解釋的問題。我們目前的結論是:1)甲基二羥苯基丙基酸代謝產物中樞之降壓反應機轉過程中,需要同時影響獨立束中腎上腺性甲-2型和乙型接受器的功能。2)甲基二羥苯基丙基酸或其代謝產物能夠取代腦幹兒茶酚胺神經傳遞物質,進而影響正常張性交感神經中樞的輸出活性能力。3)甲基二羥苯基丙基酸能夠減弱藍斑核神經原之放電活性,本反應則能據解釋為何長久病人臨床用藥經常發生鎮靜的現象。 |
英文摘要 | The neurotransmissions play in variable brainstem areas have been shown to be involved in central cardiovascular control. The role of these areas are the major targets for centrally acting hypotensive agents, most notably, methyldopa (MD). By experience from studies of three brainstem areas including nucleus tractus solitarii (NTS), ventrolateral medulla and locus coeruleus (LC), we summarize our data here on the role of central adrenergic functions and MD hypotensive mechanisms. We orient our data into three parts of conclusion, wherein each part, we will discuss the background of how we instigated our hypothesis, the aspects of neurotransmissions which might be involved, and the remained questions which still are not resolved. We suggest that: 1) both alpha₂ and beta receptors mediate the hypotensive response to MD metabolites in the NTS; 2) MD or metabolites replace brainstem catecholamines and impair the balance between these transmitters and proper tonic sympathetic outflow; and 3) MD attenuates the firing activity of LC neurons which might be related to the sedative effects of MD in man. |
本系統中英文摘要資訊取自各篇刊載內容。