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題 名 | 天竺鼠迷路動脈阻塞實驗之信度=Experimental Accuracy of Labyrinthine Artery Obstruction in Guinea Pigs |
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作 者 | 林凱南; 蘇茂昌; 許權振; | 書刊名 | 中華民國耳鼻喉科醫學會雜誌 |
卷 期 | 33:4 1998.08[民87.08] |
頁 次 | 頁24-30 |
分類號 | 416.81 |
關鍵詞 | 耳蝸血流; 缺血; 微小球; Cochlear blood flow; Ischemia; Microsphere; |
語 文 | 中文(Chinese) |
中文摘要 | 背景:血液循環障礙是內耳急性變可能的成因。動物實驗將天竺鼠迷路 動脈暫時鉗夾造成內耳暫時缺血的模式可以應用於突發性耳聾的致病機轉及藥物治療的研究 。本研究的目的是以微小球心臟灌注法來檢驗這個動物模式的實驗信度。 方法: 天竺鼠 20 隻,於麻醉及人工呼吸器輔助下,以手術法露出左側迷路動脈,將之以微小血管夾加以鉗夾 。完成後開胸將微小球溶液灌注入左心室。心跳停止後取下兩側耳蝸,固定並脫鈣,組織細 切後於顯微鏡下計算各側取蝸內微小球之含量。 有 8 隻天竺鼠在迷路動脈鉗夾之前後以雷 射杜卜勒血流測定測量血流改變。結果:20 隻天竺鼠,只有2隻 (10%) 左側耳蝸微小球數較 右側稍多,其餘 18 隻 (90%),則全都是左側 (鉗夾側 ) 微小球數目較少。 左側與右側之 比值小於 25% 者有 4 隻 (20%),小於 50% 者共有 13 隻 (65%),小於 75% 者共有 14 隻 (70%)。多數 (6/8) 用雷射杜卜勒測定法測得耳蝸血流的變化,其結果與微小球法測得的結 果相近。結論:1) 迷路動脈鉗夾造成耳蝸缺血的可信度高。2) 雷射杜卜勒血流測定法可以 快速判斷是否為有效的血管鉗夾。 |
英文摘要 | Background: Acute inner ear disease is possibly caused by vascular accident. We have used the animal model of inner ear ischemia by temporary clamping of the labyrinthine artery in the study of pathogenesis and treatment of sudden deafness. The prupose of this study is to evaluate the accuracy of this clamping method. Methods: In 20 guinea pigs, the left labyrinthine arteries were exposed surgically and clamped with microclip. Intracardiac catheterization to the left ventricle was done after thoracotmy to infuse microsphere suspension into general circulation. Bilateral temporal bones were harvested, decalcified, and sliced to count the number the microspheres trapped in the cochlea. Results: In 18 guinea pigs (90%) the number of microspheres was less on the experimental side when comparing with the control side. Only 2 (10%) showed dominant capturing of microspheres on the experimental side. The ratio of microsphere number of the experimrntal to the control side is below 25% in 4 (20%), below 50% in 13 (65%), and below 75% in 14 (70%). The results of laser Doppler flowmetry was compatible to the microsphere study in 6 of the 8 animals. Conclusions: 1) The experimental accuracy of microclip clamping of the labyrinthine artery is high. 2) Laser Doppler flowmetry can be used to evalate the effectiveness of clamping. |
本系統中英文摘要資訊取自各篇刊載內容。