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題 名 | Diffuse Scleroderma with Cancer: A Report of Two Cases and Literature Review=全身性硬皮病與惡性腫瘤兩病例報告及文獻回顧 |
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作 者 | 游恆懿; 張曉寧; 林孝義; 楊敬芬; 陳玉琨; | 書刊名 | 中華民國風濕病雜誌 |
卷 期 | 14:1/2 民86.05 |
頁 次 | 頁19-30 |
分類號 | 415.138 |
關鍵詞 | 全身性硬皮病; 惡性腫瘤; 乳癌; 卵巢癌; Diffuse scleroderma malignancy breast carcinoma ovarian carcinoma; |
語 文 | 英文(English) |
中文摘要 | 本文報告兩例全身性硬皮病合併惡性腫瘤的病例,一例為卵巢癌,在硬皮病診斷後十六年發生,另一例在硬皮病六年後發生乳癌。皮肌炎的患者罹患惡性腫瘤的比例較常人高,這已是眾所周知。而藉由文獻的回顧,發現硬皮病合併惡性腫瘤的比例也較常人高。其中乳癌和硬皮病往往有時間上的關聯,至於卵巢癌合併硬皮病則非常罕見。本文所報告的兩例患者都同時有食道逆流引起食道炎的問題,並做了外科手術治療。該卵巢癌病人最早出現的症狀是以腹脹為主,類似一般硬皮病所引起的胃腸症狀。因此假使患者有身體不適的問題,除了考慮是由硬皮病本身所致的原因之外,同時也應將腫瘤列入鑑別診斷。 |
英文摘要 | Two patients are described in whom carcinomas developed years after the detection of diffuse scleroderma. One is a 62 year-old patient whose ovarian carcinoma was found after the diagnosis of diffuse scleroderma has been made for 16 years. The other is a 49 year-old patient whose breast carcinoma was found 6 years after the diagnosis of diffuse scleroderma. Both two patients suffered from reflux esophagitis and received anti-reflux operation. Several observations made during the past few years suggest the existence of a relationship between malignancy and diffuse scleroderma. Breast cancer seemed to have close temporal relationship with the onset of diffuse scleroderma. Ovarian cancer in diffuse scleroderma is a rare condition and the initial manifestation of our patient is abdominal distention which resembled gastrointestinal involvement of scleroderma. Therefore, the manifestations of malignancy may mimic the symptoms induced by diffuse scleroderma and make the clinical course more complicated. Malignancy should always be considered in diffuse scleroderma patients especilly in old age. |
本系統中英文摘要資訊取自各篇刊載內容。