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題名 | Heparin-Binding Epidermal Growth Factor-Like Growth Factor and Transforming Growth Factor-α in Human Non-Small Cell Lung Cancers=肝素結合生長因子,轉型生長因子-α及表皮生長因子接受器在人類非小細胞癌及正常組織之表現 |
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作者 | 鍾飲文; 林繡如; 林茂生; 黃明賢; 蔡米山; 黃吉志; Chong, Inn-wen; Lin, Shiu-ru; Lin, Maw-sheng; Huang, Ming-shyan; Tsai, Mee-sun; Hwang, Jhi-jhu; |
期刊 | 臺灣醫學會雜誌 |
出版日期 | 19970800 |
卷期 | 96:8 1997.08[民86.08] |
頁次 | 頁579-585 |
分類號 | 415.53 |
語文 | eng |
關鍵詞 | 肝素結合生長因子; 轉型生長因子-α; 表皮生長因子接受器; 人類非小細胞癌; Epidermal growth factor receptor; EGFR; EGF family; TGF-α; Non-small cell lung cancer; Heparin-binding EGF-like growth factor; |
英文摘要 | Transforming growth factor-α(TGF-α), a member of the epidermal growth factor (EGF) family that binds to the EGF receptor (EGFR), is thought to function in an autocrine manner in non-small cell lung cancers (NSCLC). Heparin-binding EGF-like growth factor (HB-EGF), a novel member of the EGF family, also binds to EGFR. To compare the expression of HB-EGF, TGF-αand EGFR genes in NSCLC and normal lung tissue, we measured the levels of messenger RNA (mRNA) for these genes in human NSCLC and normal lung tissues by Northern hybridization, reverse transcription-polymerase chain reaction (RT- PCR), and in situ hybridization. A total of eight specimens (paired tumor tissue and normal lung tissue) were harvested from four patients who underwent resection of primary resectable NSCLC. HB-EGF was not expressed in either tumor tissue or normal lung tissue, while EGFR and TGF-αwere expressed in all samples. TGF-αwas overexpressed in all tumor tissue samples by several hundred-fold, while the expression of EGFR was not significantly different in tumor tissue and normal lung tissue. There was no correlation between the expression of TGF-αand EGFR. In situ hybridization showed that TGF-αmRNA was localized mainly in the cancer cells of tumor tissues and in the macrophages of alveoli in normal lung tissue. Our results showed that HB-EGF plays no role in the growth of NSCLC, and that there was no significant overexpression of EGFR in tumor tissue. TGF-αmay play a major role in the growth of NSCLC. This supports a new direction in rational NSCLC treatment. |
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