頁籤選單縮合
題名 | Clinical Isolates of Chryseobacterium indologenes:Analysis of 82 Cases=Chryseobacterium indologenes臨床菌株:82例之分析 |
---|---|
作者 | 曾政尹; 王永衛; 劉尊榮; 馮長風; 劉正義; | 書刊名 | 中華民國感染症醫學會雜誌 |
卷期 | 8:2 1997.12[民86.12] |
頁次 | 頁105-112 |
分類號 | 414.83 |
關鍵詞 | 金黃桿菌屬; Chryseobacterium indologenes; Sites of isolation; Antimicrobial susceptibility; |
語文 | 英文(English) |
中文摘要 | 雖然金黃桿菌屬(Chryseobacteria)廣泛分佈於自然界和醫院環境中,但有關Chryseobacterium indologenes對人類的致病性則仍不清楚。緣於過去文獻中對於C. indologenes在人類的確定感染症病例報告不多,自民國81年1月至民國85年4月,吾人自北部一家醫學中心82位病患的細菌培養中分離出85株C. indologenes菌株,根據取樣來源分成7組部位,並統計病患的臨床資料加以分析。該菌株在濕、冷季節的分佈較多。7組分離部份則包括尿液(41%、血液(24%)、除血液外之體液(12%)、膿液(11%)、導管相關之物質(9%)、腦脊髓液(2%)及切片組織(1%)。其中,以C. indologenes單一菌株生長者有43位病患,與其它菌株混合生長者則有39位病患,比例為1.1:1。64位病患(78%)屬院內得到,另18位病患(22%)則為社區感染。病患的臨床表現不一,包括有臨床感染症(52位病患)及單純菌落移生(30位病患);而以原發性菌血症和菌尿症占多數。主要潛在問題為癌症和免疫不全症,各有33位病患,後者包括白血球減少症、糖尿病、肝硬化症及自體免疫性疾病等四種疾患。13位病患合併有敗血症,其中只有6位病患死於因C. indologenes單純感染引起之原發性敗血症。大多數C. indologenes感染之病患最終並未死亡。所有病患之分離菌株的抗生素敏感試驗結果顯示C. indologenes對於ampicillin、cefazolin、cefonicid、gentamicin、tobramycin和vancomycin具有抗藥性。鑑於C. indologenes在某些時候可能引發人類的重大疾病,尤其是那些住院中的重症病患,未來,吾人必須更致力於研究該菌株的致病性及其在人類感染中所扮演的角色。 |
英文摘要 | Though Chryseobacteria are widespread in nature and in the hospital environment, the pathogenicity in humans of Chryseobacterium indologenes is not clear. Rather few cases of definite human infections caused by C indologenes have been reported in the previous literature. From January, 1992, to April, 1996, eighty-five isolates of C indologenes were documented from cultures of seven different groups of sites from eighty-two patients at a medical center in northern Taiwan. The cool, humid season may bring a wider distribution of this organism. The sites of isolation of this organism include urine (41%), blood (24%), body fluid (12%), pus (11%), catheter-related material (9%), cerebrospinal fluid (2%), and biopsy tissue (1%). Pure growth of C indologenes was noted in forty-three patients and mixed growth in thirty-nine patients, with a ratio of 1.1:1. Sixty-four patients (78%) were diagnosed as hospital-acquired, while eighteen patients (22%) were in the community. Patients' clinical manifestations were variable, including significant infections (fifty-two patients. 63.4%) and simple colonization (thirty patients, 36.6%), with primary bacteremia and bacteriuria predominating. The main underlying conditions were malignancy and immunocompromise (thirty-three patients each), including neutropenia, diabetes mellitus, liver cirrhosis, and autoimmune diseases. Thirteen of the patients in this study suffered sepsis syndrome, whereas only six patients died of their primary disease-related sepsis due to a pure infection of C indologenes. Most C indologenes infections were non-fatal finally (thirty-five of fifty-two patients). Antimicrobial susceptibility tests of the isolates from the eight-two patients disclosed that C indologenes was rather resistant to ampicillin, cefazolin, cefonicid, gentamicin, tobramycin, and vancomycin. Occasionally, C indologenes may be capable of causing important disease in humans, especially in hospitalized patients with severe underlying diseases. In the future, we should pay more attention to this organism's pathogenicity and its role in human infection. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。