頁籤選單縮合
題 名 | The Acting Site of Bronchodilator, Methacholine and Upper Respiratory Tract Infection on Airways=支氣管擴張劑,甲基膽鹼,及上呼吸道感染對呼吸道的作用部位 |
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作 者 | 丁燿明; 梁麗麗; 盧朝勇; | 書刊名 | 中華醫學雜誌 |
卷 期 | 60:6 1997.12[民86.12] |
頁 次 | 頁283-289 |
分類號 | 418.263 |
關鍵詞 | 呼吸道過度反應性; 最大吐氣流量; 等流量容積; Bronchial hyperreactiveness; Maximal expiratory flow rate; Volume of isoflow; |
語 文 | 英文(English) |
中文摘要 | 背景:支氣管擴張劑對慢性阻塞性肺部疾病患者是種重要藥物,甲基膽鹼是一種常見的支氣管激發藥劑,雖然支氣管擴張劑、甲基膽鹼、及上呼吸道感染的主要作用部位,在許多文章裡討論過,但是仍有一些爭論存在,故在本文中我們來探討它們在呼吸道的真正作用部位。 方法:有三十位受測者參與這個研究,上呼吸道感染的次數由問卷表得知;肺量計檢查、支氣管激發檢查、呼吸五分鐘氦氧混合氣體都在同一天做完。肺量計檢查、支氣管擴張檢、呼吸五分鐘氦氧混合氣體、及吐氣流量容積曲線在隔一天做完。ΔV□Max50表示百分之五十肺活量最大吐氣流量,在吸入氦氧混合氣體前後的變化;同時吸入支氣管擴張劑前後的百分五十肺活量最大吐氣流量,及ΔV□Max50的不同也加以計算;以這些數據來決定支氣管擴張劑的作用部位。在支氣管激發檢查後,從吸入氦氧混合氣體前後的吐氣流量容積曲線,估計出等流量容積來確定甲基膽鹼的作用部位。 結果:在這研究裡,支氣管擴張劑的作用部位在小呼吸道,甲基瞻鹼及上呼吸道感染主要地作用於大呼吸道。雖然呼吸道過度反應性常見於有陽性的甲基膽鹼反應,基準肺功能數據的恢復在有陽性的與陰性的甲基膽鹼反應患者沒有明顯的差異。 結論:支氣管擴張劑、甲基膽鹼、及上呼吸道感染的主要作用部位,分別在於小呼吸道大呼吸道。在陽性的甲基膽鹼反應者,呼吸道過度反應性並不會造成基準肺功能的快速復。 |
英文摘要 | Background. The bronchodilator agent is an important drug for patients with chronic obstructive pulmonary disease. Methacholine is a popular bronchial provocative agent. Although the major acting site of bronchodilator, methacholine and upper respiratory tract infection (URI) has been evaluated in some studies, the sites are still in debate. This study investigated the exact major acting sites. Methods. Thirty subjects participated in this study. Episodes of URI were identified by a questionnaire. Spirometry, bronchial provocative test with methacholine, and five minutes' inhalation of a mixture of helium and oxygen (HeO□) were done on day one. Spirometry, bronchodilator test, with five minutes' inhalation of HeO□) and expiratory flow-volume (F-V) curve were performed on another day. The change of pre- and post-HeO□ V□MaX50 was calculated as ΔV□Max50. The pre- and post-bronchodilator V□Max50 and ΔV□MaX50 differences were counted to decide the acting site of bronchodilator. After bronchial provocative test with methacholine, the volume of isoflow (VisoV) was estimated from pre- and post-HeO □ F-V curve to establish the acting site of methacholine. Results. This study indicated that small airways are the major acting sites of bronchodilators, large airways are the major acting sites of methacholine and URI affects mainly large airways. Although airway hyperresponsiveness is more severe in subjects with positive methacholine response, the recovery of spirometry values is not significantly different between the methacholine -positive and -negative groups. Conclusions. The major acting sites of the bronchodilator, methacholine, and URI are the small, large and large airways, respectively. Bronchial hyperresponsiveness is not a cause of quick restoration of spirometry values in subjects with positive methacholine response. |
本系統中英文摘要資訊取自各篇刊載內容。