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題 名 | Phylogenetic Analysis to Document a Common Source of Hepatitis D Virus Infection in a Mother and Her Child=以基因族譜分析證實母子間D型肝炎病毒感染的來源相同 |
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作 者 | 黃怡翔; 吳肇卿; 盧勝男; 蔣鎮宇; 張扶陽; 李壽東; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:1 1999.01[民88.01] |
頁 次 | 頁28-32 |
分類號 | 415.5332 |
關鍵詞 | 家族叢集性感染; D型肝炎病毒; 基因族譜分析; Family clustering infection; Hepatitis D virus; Phylogenetic analysis; |
語 文 | 英文(English) |
中文摘要 | 背景 母子間D型肝炎病毒的傳染相當少見,而且缺乏核酸序列的證據來證實。 本研究將感染D型肝炎病毒的雙親及小孩,以基因族譜分析法,分析他們血清中D型肝炎 病毒的基因,並比較其核酸序列。 方法 本研究收納了28位感染D型肝炎病毒的雙親(23位父親及5位母親,其中包含 2對配偶)及57位小孩,分析他們的血清抗D型肝炎病毒抗體及彼此間D型肝炎病毒的核 酸序列。基因族譜分析乃針對核�˙�911到1260片段,核酸序列與不同基因型的相似性則 以基因族譜分析加以估計。 結果 8位母親為D型肝炎病毒抗體陽性小孩中的1位,是D型肝炎病毒抗體陽性。 同一個體不同D型肝炎病毒株基因序列的差異平均為0.29-1.15%。而上述這對轉介自台南 地區的母子,其D型肝炎病毒的基因序列幾乎完全一致(99.7%);且與台北地區之D型肝炎 病毒第Ⅱ型比較,其相似性為92.2-93.4%,與台灣第Ⅰ基因型相比則為76.3-77.1%。 結論 台灣南、北地區之D型肝炎病毒第Ⅱ型,其基因序列的差異性接近8%。由基因 族譜分析發現,此對母子之D型肝炎病毒乃屬同一族群,因而支持這對母子的D型肝炎乃 來自於相同之感染源。本結果顯示,感染D型肝炎病毒的母親必須主動接受教育,其小孩 必須接種B型肝炎疫苗以預防感染。 |
英文摘要 | Background. Spread of hepatitis D virus (HDV) from mother to infant is rare and nucleotide evidence to document such transmission is lacking. The aim of this study was to screen the children of HDV-infected parents and compare the HDV nucleotide sequence between children and parents by phylogenetic analysis. Methods. Fifty-seven children of 28 HDV-infected parents (23 fathers and 5 mothers, including two couples) were enrolled. HDV genomes from sera of HDV-infected parents and their children were cloned and sequenced. Comparison and phylogenetic analysis of HDV genomes were based on a region from nucleotide 911 to 1260. The homology to nucleotide sequence among different genotypes was estimated by phylogenetic analysis. Results. One of the eight children whose mothers were anti-HDV positive was positive for anti- HDV. Mean heterogeneity among different HDV clones from a single subject ranged from 0.29% to 1.15%. HDV sequences from the mother and her child (referred from southern Taiwan) were nearly identical (99.7%), both showed 92.2-93.4% homology with other genotype Ⅱ isolates from north Taiwan and 76.3-77.1% homology with genotype I isolates. Conclusions. Genotype Ⅱ HDV is most prevalent in Taiwan. There are significant variations up to 8% in nucleotide sequence among different genotype Ⅱ HDV clones isolated from patients in northern and southern Taiwan. Phylogenetic analysis revealed that HDV clones from the mother and her child form a monophyletic group, supporting a common source of infection. Susceptible children of HDV-infected mothers should be protected by hepatitis B virus vaccination and active education. |
本系統中英文摘要資訊取自各篇刊載內容。