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| 題 名 | The Effects of Topical Superoxide Dismutase Gel on Healing of Burn Wounds--A Preliminary Report=局部塗抹超氧化物轉化酶膠對燒傷傷口癒合之影響--初步結果報告 |
|---|---|
| 作 者 | 黃乾誠; 方榮煌; | 書刊名 | 中華民國外科醫學會雜誌 |
| 卷 期 | 28:5 民84.09-10 |
| 頁 次 | 頁387-392 |
| 分類號 | 416.141 |
| 關鍵詞 | 超氧化物; 轉化酶膠; 燒傷; 傷口癒合; Burn; Superoxide dismutase gel; Wound healing; |
| 語 文 | 英文(English) |
| 中文摘要 | 燒傷病人以靜脈注射方式投予超氧化物轉化酶,可清除過氧自由基,抑制脂肪過氧化及促進燒傷傷口癒合。局部塗抹超氧化物轉化酶膠對燒傷傷口癒合的影響,則末有定論。自1992年4月至12 月間,選擇了10位2至3度燒傷,面積佔體表面積百分之三十至九十之病人,以雙盲方式,每位病人選擇兩塊十公分見方,外觀等深之燒傷傷口,分別以超氧化物轉化酶膠及安慰劑,局部每天塗抹兩次,連續七天。自第五天至十四天,每天記錄並計算癒合面積之百分比。燒傷傷口局部塗抹試藥後,均較乾燥且沒有感染情況出現。在傷後第七天,局部塗抹超氧化物轉化酶膠及安慰劑之兩組,其傷口平均癒合百分率分別為:61.7±21.2%和40.8±17.6% (p value<0.005, paired Students' t test)有統計上差異。這兩組的傷口癒合百分率,自第五天至第十四天,均有統計意義的差異(p value<0.0l, paired Students't test)。在燒傷後七天內,每天兩次以0.1%超氧化物轉化酶膠局部塗抹於2度燒傷傷口,確能增快傷口之癒合。然而,超氧化物轉化酶膠局部塗抹於一般燒傷傷口之效果,則有待進一步研究。 |
| 英文摘要 | Intravenous administration of superoxide dismutase (SOD) can scavenge oxygen radicals, inhibit lipid peroxidation and accelerate burn wound healing in burn patients. However, the effect of topical SOD gel used over the burn wounds has not been well documented. Cu, Zn-SOD gel, 0.1% [ SOD (+) gel ] and the placebo [ SOD (-)gel ] were applied over two areas of second degree burn wounds, 10 x 10 cm2 each in size, twice a day for seven days following burn, in a double-blind method. The percentage of healed area (re-epithelialization) of burn wound was calculated and recorded from the 5th to the 14th days in 10 patients who had suffered from second to third degree burn, 30% to 90% total body surface area (TBSA). There was significant difference in the mean percentage of healed area between the two groups from the 5th to the 14th days fol1owing burn injury (p<0.01, by paired Students' t test). The mean percentage of healed area in SOD (+) and SOD (-)groups the seventh day after topical application of the gel were 61.3±21.1%, and 40.8±17.6% respectively, a significant statistic difference (p<0.0005 by paired Students't test). Topical use of Cu, Zn-SOD gel, 0.1%,twice a day from the first to the seventh days after burn injury over the wound significantly accelerated re-epithelialization and wound healing clinically. |
本系統中英文摘要資訊取自各篇刊載內容。